Title:
PREVENTIVE AND REMEDY FOR DRY EYE ASSOCIATED WITH CHRONIC GRAFT VERSUS HOST DISEASE
Document Type and Number:
WIPO Patent Application WO/2006/073126
Kind Code:
A1
Abstract:
It is intended to provide a medicinal composition for preventing and treating dye eye associated with chronic graft versus host disease (cGVHD) following the transplantation of hematopoietic stem cells. Namely, a medicinal composition or the like for preventing and treating dye eye associated with GVHD occurring after the transplantation of hematopoietic stem cells such as peripheral blood stem cell transplantation, cord blood transplantation or bone marrow transplantation which contains as the active ingredient N-(3,4-dimethoxycinnamoyl)anthranilic acid (common name: tranilast) or a pharmacologically acceptable salt thereof.
Inventors:
OGAWA YOKO (JP)
Application Number:
PCT/JP2005/024151
Publication Date:
July 13, 2006
Filing Date:
December 29, 2005
Export Citation:
Assignee:
KISSEI PHARMACEUTICAL (JP)
OGAWA YOKO (JP)
OGAWA YOKO (JP)
International Classes:
A61K31/196; A61P27/04; A61P37/06
Domestic Patent References:
| WO2001005394A1 | 2001-01-25 | |||
| WO1998013038A1 | 1998-04-02 | |||
| WO1998016214A1 | 1998-04-23 | |||
| WO1998035668A1 | 1998-08-20 | |||
| WO1997037650A1 | 1997-10-16 | |||
| WO1998047504A1 | 1998-10-29 |
Foreign References:
| JPH09176003A | 1997-07-08 |
Other References:
ISAJI M. ET AL.: "Selective inhibition of collagen accumulation by N-(3,4-dimethoxycin namoyl)anthranilic acid (N-5') in granulation tissue", BIOCHEMICAL PHARMACOLOGY, vol. 36, no. 4, 1987, pages 469 - 474, XP000995000
KUWANA M.: "Zenshinsei Jiko Men'eki Shikkan ni Okeru Nanjisei Byotai no Shindan to Chiryoho ni Kansuru Kenkyu Sen'ika Byotai ni Okeru Seniga Saibo to T Saibo no Kyocho Sayo ni Kansuru Kenkyu", ZENSHINSEI JIKO MEN'EKI SHIKKAN NI OKERU NANJISEI BYOTAI NO SHINDAN TO CHIRYOHO NI KANSURU KENKYU HEISEI 14 NENDO SOKATSU, 2003, pages 21 - 23, XP003000551
MATSUMOTO Y.: "Graft-versus-host disease (GVHD) no me no Chiryo", SHIKAGAKUHO, vol. 104, no. 2, 2004, pages 121 - 123, XP003000552
KUWANA M.: "Zenshinsei Jiko Men'eki Shikkan ni Okeru Nanjisei Byotai no Shindan to Chiryoho ni Kansuru Kenkyu Sen'ika Byotai ni Okeru Seniga Saibo to T Saibo no Kyocho Sayo ni Kansuru Kenkyu", ZENSHINSEI JIKO MEN'EKI SHIKKAN NI OKERU NANJISEI BYOTAI NO SHINDAN TO CHIRYOHO NI KANSURU KENKYU HEISEI 14 NENDO SOKATSU, 2003, pages 21 - 23, XP003000551
MATSUMOTO Y.: "Graft-versus-host disease (GVHD) no me no Chiryo", SHIKAGAKUHO, vol. 104, no. 2, 2004, pages 121 - 123, XP003000552
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