PRIMERS AND PROBE FOR DETECTING PRESENCE OF BLADDER CANCER

WIPO Patent Application WO/2023/145754

A1

The present invention provides a primer set for detecting the presence of bladder cancer in a specimen, said primer set containing a pair of primers that are oligonucleotides targeting a PLEKHS1 promoter mutation and having a length of 16-21 bases inclusive, and one or more pairs of primers targeting a TERT promoter mutation.

WO/1993/018186	COMPARATIVE GENOMIC HYBRIDIZATION (CGH)
WO2000073422	GENETICALLY MODIFIED PLANT CELLS AND PLANTS WITH AN INCREASED ACTIVITY OF AN AMYLOSUCRASE PROTEIN AND A BRANCHING ENZYME
JP2021521855	Design and delivery of homologous recombination repair templates for editing hemoglobin-related mutations

TSUKAHARA SHIGEHIRO (JP)
MATSUMOTO TAKASHI (JP)
SHIOTA MASAKI (JP)
ETO MASATOSHI (JP)
KANG DONGCHON (JP)
KODAMA KEISUKE (JP)

PCT/JP2023/002178

August 03, 2023

January 25, 2023

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DENKA COMPANY LTD (JP)
UNIV KYUSHU NAT UNIV CORP (JP)

C12N15/09; C12Q1/686; C12Q1/6886

WU SONG, OU TONG, XING NIANZENG, LU JIANG, WAN SHENGQING, WANG CHANGXI, ZHANG XI, YANG FEIYA, HUANG YI, CAI ZHIMING: "Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer", NATURE COMMUNICATIONS, vol. 10, no. 1, XP093080485, DOI: 10.1038/s41467-019-08576-5
BAXTER L., GORDON N. S., OTT S., WANG J., PATEL P., GOEL A., PIECHOCKI K., SILCOCK L., SALE C., ZEEGERS M. P., CHENG K. K., JAMES : "Properties of non-coding mutation hotspots as urinary biomarkers for bladder cancer detection", SCIENTIFIC REPORTS, vol. 13, no. 1, XP093080486, DOI: 10.1038/s41598-023-27675-4

INABA, Yoshiyuki et al. (JP)

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