Title:
PROCESS EMPLOYING CONTROLLED CRYSTALLIZATION IN FORMING CRYSTALS OF A PHARMACEUTICAL
Document Type and Number:
WIPO Patent Application WO/2005/108380
Kind Code:
A2
Abstract:
A process is provided which employs reactive controlled crystallization to produce drug substance having desirable crystal properties which process involves providing reactants A and B in liquid or solution form and adding reactant B to reactant A using a cubic or incremental addition technique to control extent of reaction and thus crystallization kinetics, including supersaturation and nucleation, to produce crystals of drug substance which are generally larger, better quality and with few fines and narrow particle size distribution than normally obtainable employing prior art crystallization techniques. In addition, crystals of drug substance produced by the above process is also provided.
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Inventors:
KIM SOOJIN (US)
WEI CHENKOU (US)
LINDRUD MARK (US)
CHUNG HYEI-JHA (US)
WEI CHENKOU (US)
LINDRUD MARK (US)
CHUNG HYEI-JHA (US)
Application Number:
PCT/US2005/015338
Publication Date:
November 17, 2005
Filing Date:
May 03, 2005
Export Citation:
Assignee:
BRISTOL MYERS SQUIBB CO (US)
KIM SOOJIN (US)
WEI CHENKOU (US)
LINDRUD MARK (US)
CHUNG HYEI-JHA (US)
KIM SOOJIN (US)
WEI CHENKOU (US)
LINDRUD MARK (US)
CHUNG HYEI-JHA (US)
International Classes:
C07D213/42; C07D263/32; C07D263/34; (IPC1-7): C07D263/34
Foreign References:
| USPP57239704P | 2004-05-19 |
Other References:
JONES; MULLIN, CHEM. ENG. SCI., vol. 29, 1974, pages 105
See also references of EP 1758664A4
See also references of EP 1758664A4
Attorney, Agent or Firm:
Rodney, Burton (P.O. Box 4000 Princeton, NJ, US)
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