Title:
PROCESS FOR THE PREPARATION OF A PHARMACEUTICAL INTERMEDIATE
Document Type and Number:
WIPO Patent Application WO1999057095
Kind Code:
A3
Abstract:
The invention relates to a process for the preparation of (+/-)-4-(S,R)- [(3,4-dichlorophenyl) -3,4-dihydro-1(2H) -naphthalene-1-ylidene] -methylamine of Formula (I) by reacting 4-(3,4-dichlorophenyl) -3,4-dihydro-1(2H) -naphthalene-1-one of Formula (II) with methyl amine which comprises carrying out the reaction in the absence of a dehydrating agent, in a lower alkanol. The compound of Formula (I) is a useful pharmaceutical intermediate.
Inventors:
SIMIG GYULA (HU)
KOTAY NAGY PETER (HU)
BARKOCZY JOZSEF (HU)
KRASZNAI GYOERGY (HU)
NAGY KALMAN (HU)
VERECZKEYNE DONATH GYOERGYI (HU)
NEMETH NORBERT (HU)
SZABO TIBOR (HU)
SZTRUHAR ILONA (HU)
LADANYI LASZLO (HU)
BALAZS LASZLO (HU)
DOMAN IMRE (HU)
GREFF ZOLTAN (HU)
RATKAI ZOLTAN (HU)
SERES PETER (HU)
KOTAY NAGY PETER (HU)
BARKOCZY JOZSEF (HU)
KRASZNAI GYOERGY (HU)
NAGY KALMAN (HU)
VERECZKEYNE DONATH GYOERGYI (HU)
NEMETH NORBERT (HU)
SZABO TIBOR (HU)
SZTRUHAR ILONA (HU)
LADANYI LASZLO (HU)
BALAZS LASZLO (HU)
DOMAN IMRE (HU)
GREFF ZOLTAN (HU)
RATKAI ZOLTAN (HU)
SERES PETER (HU)
Application Number:
PCT/HU1999/000034
Publication Date:
January 13, 2000
Filing Date:
May 03, 1999
Export Citation:
Assignee:
EGYT GYOGYSZERVEGYESZETI GYAR (HU)
SIMIG GYULA (HU)
KOTAY NAGY PETER (HU)
BARKOCZY JOZSEF (HU)
KRASZNAI GYOERGY (HU)
NAGY KALMAN (HU)
VERECZKEYNE DONATH GYOERGYI (HU)
NEMETH NORBERT (HU)
SZABO TIBOR (HU)
SZTRUHAR ILONA (HU)
LADANYI LASZLO (HU)
BALAZS LASZLO (HU)
DOMAN IMRE (HU)
GREFF ZOLTAN (HU)
RATKAI ZOLTAN (HU)
SERES PETER (HU)
SIMIG GYULA (HU)
KOTAY NAGY PETER (HU)
BARKOCZY JOZSEF (HU)
KRASZNAI GYOERGY (HU)
NAGY KALMAN (HU)
VERECZKEYNE DONATH GYOERGYI (HU)
NEMETH NORBERT (HU)
SZABO TIBOR (HU)
SZTRUHAR ILONA (HU)
LADANYI LASZLO (HU)
BALAZS LASZLO (HU)
DOMAN IMRE (HU)
GREFF ZOLTAN (HU)
RATKAI ZOLTAN (HU)
SERES PETER (HU)
International Classes:
C07C249/02; C07C251/20; (IPC1-7): C07C249/02; C07C251/20; C07C251/18
Domestic Patent References:
| WO1999036394A1 | 1999-07-22 |
Foreign References:
| US4536518A | 1985-08-20 | |||
| US4855500A | 1989-08-08 |
Other References:
OSHIRO Y ET AL: "Novel cerebroprotective agents with central nervous system stimulating activity. 1. Synthesis and pharmacology of the 1-amino-7-hydroxyindan derivatives", JOURNAL OF MEDICINAL CHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. WASHINGTON, vol. 34, pages 2004-2013, XP002113231, ISSN: 0022-2623
Download PDF: