PROCESS FOR THE PREPARATION OF A PIPERAZINE DERIVATIVE

Title:

PROCESS FOR THE PREPARATION OF A PIPERAZINE DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/2001/025185

Kind Code:

A1

Abstract:

A process for the preparation of a piperazine derivative of formula (V), which comprises reacting 1-methyl -3-phenylpiperazine with 2-chloro-3-cyanopyridine in the presence of a base and an alkali metal halide in an aprotic polar organic solvent. This piperazine derivative and its oxalate are useful as intermediates for the preparation of mirtazapine.

Inventors:

MAEDA CHIHARU (JP)
IISHI EIICHI (JP)
WANG WEIGI (JP)
IMAMIYA YOSHIYUKI (JP)

Application Number:

PCT/JP2000/005432

Publication Date:

April 12, 2001

Filing Date:

August 14, 2000

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Assignee:

SUMIKA FINE CHEMICALS CO LTD (JP)
MAEDA CHIHARU (JP)
IISHI EIICHI (JP)
WANG WEIGI (JP)
IMAMIYA YOSHIYUKI (JP)

International Classes:

C07C209/74; C07C211/29; C07C213/04; C07C215/30; C07D213/85; (IPC1-7): C07C215/30; C07C213/04; C07C211/29; C07C209/74; C07D241/04; C07D401/04

Foreign References:

US4217452A	1980-08-12
JPS4417388B1	1969-07-31
US4062848A	1977-12-13

Attorney, Agent or Firm:

Hosoda, Yoshinori (Otemae M2 Building 8-1, Tanimachi 2-chome, Chuo-k, Osaka-chi Osaka, JP)

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