PROCESS FOR THE PREPARATION OF SUBSTITUTED TRIAZOLE COMPOUNDS

Title:

PROCESS FOR THE PREPARATION OF SUBSTITUTED TRIAZOLE COMPOUNDS

Document Type and Number:

WIPO Patent Application WO2005077922

Kind Code:

A3

Abstract:

The present invention is directed to a novel process for the preparation of substituted triazole compounds of formula: (I); wherein R1 and R2 are as defined in the claims, useful in the treating or ameliorating a selective kinase or dual-kinase mediated disorder. The process of the present invention preferentially produces the desired regioisomer of the substituted triazole compounds.

Inventors:

PALMER DAVID C (US)
SORGI KIRK L (US)
CESCO-CANCIAN SERGIO (US)
XIAO TONG (US)

Application Number:

PCT/US2005/001917

Publication Date:

January 26, 2006

Filing Date:

January 21, 2005

Export Citation:

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Assignee:

JANSSEN PHARMACEUTICA NV (BE)
PALMER DAVID C (US)
SORGI KIRK L (US)
CESCO-CANCIAN SERGIO (US)
XIAO TONG (US)

International Classes:

C07D249/14; A61K31/4196; A61K31/427; A61K31/4439; A61K31/444; A61P35/00; C07D401/06; C07D401/12; C07D401/14; C07D405/06; C07D409/06; C07D417/06; C07D417/12

Domestic Patent References:

WO2002057240A1	2002-07-25
WO2004046120A2	2004-06-03

Other References:

REITER J ET AL: "ON TRIAZOLES. VI 1. THE ACYLATION OF 5-AMINO-1,2,4-TRIAZOLES", JOURNAL OF HETEROCYCLIC CHEMISTRY, HETEROCORPORATION. PROVO, US, vol. 24, no. 1, January 1987 (1987-01-01), pages 127 - 142, XP001083715, ISSN: 0022-152X
FISCHER, EBERHARD ET AL: "The reaction behavior of N-(ethoxycarbonyl)-N'-cyano-S-methylisothiourea", ZEITSCHRIFT FUER CHEMIE , 17(2), 59-60 CODEN: ZECEAL; ISSN: 0044-2402, 1977, XP009051437

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