Title:
PROCESS FOR PREPARATION OF VOGLIBOSE
Document Type and Number:
WIPO Patent Application WO/2003/080561
Kind Code:
A1
Abstract:
The invention provides a process by which voglibose can be safely and easily prepared at a low cost&semi intermediates favorably usable in the process&semi and a process for preparation of the intermediates, specifically, inositol derivatives represented by the general formula (VI): (VI) (wherein Prt is a hydroxyl−protecting group)&semi a process for the preparation of the inositol derivatives which comprises dihydroxyaminating a cyclohexanone compound represented by the general formula (IV): (IV) (wherein Prt is as defined above) with a dihydroxyaminating agent and a reducing agent&semi and a process for the preparation of voglibose represented by formula (VIII): (VIII) which comprises oxidizing an inositol derivative of the general formula (VI) and deblocking the resulting inositol compound.
Inventors:
SHOGAKI TAKESHI (JP)
KAKITA TAKAO (JP)
YAGI SUGURU (JP)
KAKITA TAKAO (JP)
YAGI SUGURU (JP)
Application Number:
PCT/JP2002/010687
Publication Date:
October 02, 2003
Filing Date:
October 15, 2002
Export Citation:
Assignee:
SAWAI SEIYAKU KK (JP)
SHOGAKI TAKESHI (JP)
KAKITA TAKAO (JP)
YAGI SUGURU (JP)
SHOGAKI TAKESHI (JP)
KAKITA TAKAO (JP)
YAGI SUGURU (JP)
International Classes:
C07C213/00; C07C213/02; C07C217/52; C07C215/44; (IPC1-7): C07C217/52; C07C213/00; C07C213/02; C07C215/42
Foreign References:
| EP0260121A2 | 1988-03-16 | |||
| EP0240175A1 | 1987-10-07 |
Other References:
FERRIER ROBERT J. ET AL.: "Functionalized carbocycles from carbohydrates. Part 12", CARBOHYDRATE RESEARCH, vol. 205, 1990, pages 283 - 291, XP002962308
Attorney, Agent or Firm:
Hosoda, Yoshinori c/o Hosoda International Patent Office (OMM Building 5th Floor P.O.Box 26, 7-31,
Otemae 1-chome, Chuo-k, Osaka-shi Osaka, JP)
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