PROCESS FOR PREPARING DOXORUBICIN - PHARMACIA & UPJOHN SPA

Title:

PROCESS FOR PREPARING DOXORUBICIN

Document Type and Number:

WIPO Patent Application WO1998039458

Kind Code:

A8

Abstract:

The present invention is directed to a process for improving daunorubicin and doxorubicin production by means of a recombinant microorganism in which a gene of daunorubicin metabolism is mutated. The mutated gene is preferably dnrU and/or dnrX.

Inventors:

FILIPPINI SILVIA (IT)
LOMOVSKAYA NATALIA (US)
FONSTEIN LEONID (US)
COLOMBO ANNA LUISA (IT)
HUTCHINSON C RICHARD (US)
OTTEN SHAREE L (US)
BREME UMBERTO (IT)

Application Number:

PCT/US1998/003938

Publication Date:

April 08, 1999

Filing Date:

March 05, 1998

Export Citation:

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Assignee:

PHARMACIA & UPJOHN SPA (IT)
FILIPPINI SILVIA (IT)
LOMOVSKAYA NATALIA (US)
FONSTEIN LEONID (US)
COLOMBO ANNA LUISA (IT)
HUTCHINSON C RICHARD (US)
OTTEN SHAREE L (US)
BREME UMBERTO (IT)

International Classes:

C12N1/21; C12P19/56; (IPC1-7): C12N15/76; C12N1/21; C12P19/56

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