Title:
PROCESS FOR PRODUCING ARALKYLAMINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2002/096853
Kind Code:
A1
Abstract:
An aromatic aldehyde derivative represented by the general formula (1): Ar−CHO (1) (wherein Ar represents an aromatic group) is reacted with trichlorosilane and a carbamate represented by the general formula (2): NH2COOR (2) (wherein R represents alkyl or aralkyl) to obtain an aralkyl derivative of the carbamate, the derivative being represented by the general formula Ar−CH2−B (wherein Ar and R have the same meanings as defined above and B represents hydrogen or −COOR). According to need, this derivative is subjected to a reaction for eliminating the protective group to obtain an aralkylamine derivative represented by the general formula Ar−CH2−NH2 (wherein Ar has the same meaning as defined above).
Inventors:
HAMADA YUSUKE (JP)
UMEZU KAZUTO (JP)
YOSHIDA YASUO (JP)
UMEZU KAZUTO (JP)
YOSHIDA YASUO (JP)
Application Number:
PCT/JP2002/005123
Publication Date:
December 05, 2002
Filing Date:
May 27, 2002
Export Citation:
Assignee:
IHARA CHEMICAL IND CO (JP)
HAMADA YUSUKE (JP)
UMEZU KAZUTO (JP)
YOSHIDA YASUO (JP)
HAMADA YUSUKE (JP)
UMEZU KAZUTO (JP)
YOSHIDA YASUO (JP)
International Classes:
C07C209/62; C07C269/00; (IPC1-7): C07C211/29; C07C209/60; C07C209/62; C07C269/00; C07C271/12; C07C271/14
Domestic Patent References:
| WO1998050368A1 | 1998-11-12 |
Other References:
DUBE D. ET AL.: "Reductive N-alkylation of amides, carbamates and ureas", TETRAHEDRON LETTERS, vol. 40, 1999, pages 2295 - 2298, XP004157456
NAGAI Y.: "Hydrosilanes as reducing agents. A review", ORGANIC PREPARATIONS AND PROCEDURES INT., vol. 12, no. 1-2, 1980, pages 13, 15-48, XP002955810
NAGAI Y.: "Hydrosilanes as reducing agents. A review", ORGANIC PREPARATIONS AND PROCEDURES INT., vol. 12, no. 1-2, 1980, pages 13, 15-48, XP002955810
Attorney, Agent or Firm:
Ishida, Takashi (ISHIDA & ASSOCIATES Toranomon 37 Mori
Bldg. 5-, Toranomon 3-chome Minato-ku Tokyo, JP)
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