PROCESS FOR PRODUCING LARGE CYCLIC KETONE AND INTERMEDIATE THEREFOR

Title:

PROCESS FOR PRODUCING LARGE CYCLIC KETONE AND INTERMEDIATE THEREFOR

Document Type and Number:

WIPO Patent Application WO/2006/051595

Kind Code:

A1

Abstract:

A process for producing muscone by methyl addition to the 1,4-conjugation of 2-cyclopentadecenone. By the process, muscone is produced in high yield not under reaction conditions including an extremely low temperature and a low concentration but under practical conditions. The process comprises subjecting 2-cyclopentadecenone to a 1,4-conjugation addition reaction with an organometallic methylation reagent in the presence of a copper catalyst or nickel catalyst and an enol anion-trapping agent to obtain a 3-methyl-1-cyclopentadecene derivative represented by the general formula (II): (II) and then solvolyzing the enol moiety of this 3-methyl-1-cyclopentadecene derivative to obtain muscone.

Inventors:

MATSUDA HIROYUKI (JP)
TANAKA SHIGERU (JP)

Application Number:

PCT/JP2004/016767

Publication Date:

May 18, 2006

Filing Date:

November 11, 2004

Export Citation:

Click for automatic bibliography generation Help

Assignee:

TAKASAGO PERFUMERY CO LTD (JP)
MATSUDA HIROYUKI (JP)
TANAKA SHIGERU (JP)

International Classes:

C07C69/96; C07C45/51; C07C49/587; C07C67/00; C07C68/06; C07C69/22; (IPC1-7): C07C69/96; C07C68/06; C07C69/22; C07C67/00; C07C49/587; C07C45/51

Foreign References:

JPH07267968A

1995-10-17

Other References: