PROCESS FOR PRODUCING OPTICALLY ACTIVE 1-ALKYL-SUBSTITUTED 2,2,2-TRIFLUOROETHYLAMINE

Title:

PROCESS FOR PRODUCING OPTICALLY ACTIVE 1-ALKYL-SUBSTITUTED 2,2,2-TRIFLUOROETHYLAMINE

Document Type and Number:

WIPO Patent Application WO/2004/110977

Kind Code:

A1

Abstract:

A process for producing an optically active, 1-alkyl-substituted 2,2,2-trifluoroethylamine represented by the formula [3] (wherein R represents C_1-6 alkyl and * indicates asymmetric carbon) or a salt of the compound. These compounds are important intermediates for medicines and agricultural chemicals. The process comprises asymmetrically reducing an optically active imine represented by the formula [1] with the aid of a catalyst comprising a Group VIII metal in a hydrogen atmosphere to convert it to an optically active secondary amine represented by the formula [2] and subjecting the secondary amine or a salt thereof to hydrogenolysis to produce the target compound.

Inventors:

ISHII AKIHIRO (JP)
KURIYAMA YOKUSU (JP)
YASUMOTO MANABU (JP)
KANAI MASATOMI (JP)
INOMIYA KENJIN (JP)
OOTSUKA TAKASHI (JP)
UEDA KOJI (JP)

Application Number:

PCT/JP2004/007955

Publication Date:

December 23, 2004

Filing Date:

June 08, 2004

Export Citation:

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Assignee:

CENTRAL GLASS CO LTD (JP)
ISHII AKIHIRO (JP)
KURIYAMA YOKUSU (JP)
YASUMOTO MANABU (JP)
KANAI MASATOMI (JP)
INOMIYA KENJIN (JP)
OOTSUKA TAKASHI (JP)
UEDA KOJI (JP)

International Classes:

C07B53/00; C07B61/00; C07C209/62; C07C211/15; C07C249/02; C07C209/52; C07C251/08; (IPC1-7): C07C209/52; C07C209/62; C07C211/15; C07B53/00; C07B61/00

Foreign References:

JP2002030048A	2002-01-29
JPH10182578A	1998-07-07

Other References: