PROCESS FOR PRODUCING OPTICALLY ACTIVE CHROMAN DERIVATIVE AND INTERMEDIATE

WIPO Patent Application WO/2003/040382

A1

A process for easily producing from an inexpensive material various kinds of optically active chroman derivatives useful as intermediates for medicines, etc. A cyclic hemiacetal (1) obtained from dihydrocoumarin through one step is converted to an optically active halohydrin derivative (3) through an asymmetric reduction reaction, and the derivative (3) is cyclized to produce an optically active chroman derivative (13).

MITSUDA MASARU (JP)
TANAKA TATSUYOSHI (JP)
YASOHARA YOSHIHIKO (JP)

PCT/JP2002/011592

May 15, 2003

November 07, 2002

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KANEKA CORP (JP)
MITSUDA MASARU (JP)
TANAKA TATSUYOSHI (JP)
YASOHARA YOSHIHIKO (JP)

C07C39/24; C07C303/28; C07C303/30; C07C309/66; C07D311/20; C07D405/06; C12P7/22; C07C309/73; (IPC1-7): C12P17/06; C07C39/24; C07C309/66; C07D311/20; C07D311/58; C12P7/22

GB1296431A	1972-11-15
EP0539803A1	1993-05-05
EP0707007A1	1996-04-17
EP0702010A1	1996-03-20

SUDA M. ET AL.: "Dichloromethylenation of esters and lactones by triphenylphosphine-carbon tetrachloride reagent", TETRAHEDRON LETT., vol. 22, no. 8, 1981, pages 759 - 762, XP002961034
YANG D. ET AL.: "Regioselective intramolecular oxidation of phenols and anisoles by dioxiranes generated in situ", J. ORG. CHEM., vol. 65, no. 13, 2000, pages 4179 - 4184, XP002961035
See also references of EP 1445324A4

Asahina, Sohta (2-22 Tanimachi 2-chom, Chuo-ku Osaka-shi Osaka, JP)

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