PROCESS FOR PRODUCING PAROXETINE SALT CONTAINING SUBSTANTIALLY NO ORGANIC SOLVENT

Title:

PROCESS FOR PRODUCING PAROXETINE SALT CONTAINING SUBSTANTIALLY NO ORGANIC SOLVENT

Document Type and Number:

WIPO Patent Application WO/2002/022609

Kind Code:

A1

Abstract:

A process for producing a paroxetine salt containing no organic solvents by substantially and safely removing the organic solvent contained in paroxetine hydrochloride. The process comprises neutralizing paroxetine hydrochloride containing an organic solvent to form paroxetine, subsequently forming a salt of paroxetine with an acid other than hydrochloric acid, and crystallizing the salt from an organic solvent to obtain the paroxetine salt, which is not a hydrochloride.

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Inventors:

WANG SHU-ZHONG (JP)
SAITO ERIKA (JP)
SHIMOKAWA NAOYA (JP)

Application Number:

PCT/JP2001/007967

Publication Date:

March 21, 2002

Filing Date:

September 13, 2001

Export Citation:

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Assignee:

ASAHI GLASS CO LTD (JP)
WANG SHU ZHONG (JP)
SAITO ERIKA (JP)
SHIMOKAWA NAOYA (JP)

International Classes:

A61K31/4525; A61P25/16; A61P25/24; A61P43/00; C07D405/12; (IPC1-7): C07D405/12

Domestic Patent References:

WO2000039121A1	2000-07-06
WO1998056787A1	1998-12-17
WO1996024595A1	1996-08-15

Foreign References:

EP0810224A1

1997-12-03

Attorney, Agent or Firm:

Senmyo, Kenji (Kanda-Higashimatsushitacho Chiyoda-ku, Tokyo, JP)

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