PROCESS FOR PRODUCING PREGNANE DERIVATIVE

Title:

PROCESS FOR PRODUCING PREGNANE DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/2003/051904

Kind Code:

A1

Abstract:

A process for producing a 21−hydroxypregnane derivative represented by the general formula (III), (III) characterized by protecting the 7−position hydroxy group of a compound represented by the formula (I) (I) and subsequently eliminating the 21−position protective silyl group. (In the formulae, R¹, R², and R³ each independently represents optionally substituted alkyl, alkenyl, alkynyl, aryl, or aralkyl&semi and R⁴ represents a hydroxy−protecting group.) By the process, a pregnane derivative useful as, e.g., an intermediate for squalamine can be efficiently produced through a small number of steps from easily available materials.

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Inventors:

NAKAZAWA MAKOTO (JP)
OHZONO SHIGEO (JP)

Application Number:

PCT/JP2002/011547

Publication Date:

June 26, 2003

Filing Date:

November 06, 2002

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Assignee:

KURARAY CO (JP)
NAKAZAWA MAKOTO (JP)
OHZONO SHIGEO (JP)

International Classes:

C07J5/00; C07J75/00; (IPC1-7): C07J5/00; C07J75/00

Domestic Patent References:

WO2002020552A1

2002-03-14

Other References:

HONG-SEOK KIM ET AL., BIOORG. MED. CHEM., vol. 8, no. 8, 2000, pages 2059 - 2065, XP002949909

Attorney, Agent or Firm:

Takashima, Hajime (Fushimimachi 4-chome Chuo-ku Osaka-shi, Osaka, JP)

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