Title:
TAOJIKS AS MODIFIERS OF THE BETA-CATENIN PATHWAY AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO2003051905
Kind Code:
A3
Abstract:
Human TAOJIK genes are identified as modulators of the beta-catenin pathway, and thus are therapeutic targets for disorders associated with defective beta-catenin function. Methods for identifying modulators of beta-catenin, comprising screening for agents that modulate the activity of TAOJIK are provided.
Inventors:
COSTA MICHAEL A
GENDREAU STEVEN BRIAN
DORA EMERY G III
NICOLL MONIQUE
URBANI LENORE
LARSON JEFFREY S
GENDREAU STEVEN BRIAN
DORA EMERY G III
NICOLL MONIQUE
URBANI LENORE
LARSON JEFFREY S
Application Number:
PCT/US2002/039742
Publication Date:
October 16, 2003
Filing Date:
December 12, 2002
Export Citation:
Assignee:
EXELIXIS INC (US)
International Classes:
A61K45/00; A61P9/00; A61P35/00; A61P43/00; C12N15/09; C12Q1/02; C12Q1/48; C12Q1/68; G01N33/15; G01N33/50; G01N33/574; (IPC1-7): A61K38/00
Other References:
TASSI E. ET AL.: "Human JIK, a novel member of the STE20 kinase family that inhibits JNK and is negatively regulated by epidermal growth factor", J. BIOL. CHEM., vol. 274, no. 47, 19 November 1999 (1999-11-19), pages 33287 - 33295, XP002965003
See also references of EP 1453532A4
See also references of EP 1453532A4
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