Title:
PROCESS FOR PRODUCING PROTEIN A-LIKE PROTEIN WITH USE OF BREVIBACILLUS GENUS BACATERIUM
Document Type and Number:
WIPO Patent Application WO/2006/004067
Kind Code:
A1
Abstract:
An efficient and economically advantageous process for producing a protein A-like protein. In the production of a protein A-like protein utilizing the technology of genetic manipulation, use is made of a host, such as Escherichia coli or Bacillus subtilis, which however results in low productivity becoming a major cause of high cost. Consequently, there is a strong demand on rapid establishment of a technology capable of low-cost mass production of a protein A-like protein with the use of recombinant DNA technology other than that employing Escherichia coli or Bacillus subtilis. Accordingly, there is provided, for example, a process for massproduction of a protein A-like protein, comprising realizing mass secretion expression of the protein with the use of recombinant Brevibacillus genus bacteria into a culture solution and carrying out separation and recovery of accumulated protein A-like protein from the culture solution.
Inventors:
KOSUGI AKIHIKO (JP)
YAJIMA KAZUYOSHI (JP)
YAJIMA KAZUYOSHI (JP)
Application Number:
PCT/JP2005/012252
Publication Date:
January 12, 2006
Filing Date:
July 01, 2005
Export Citation:
Assignee:
KANEKA CORP (JP)
KOSUGI AKIHIKO (JP)
YAJIMA KAZUYOSHI (JP)
KOSUGI AKIHIKO (JP)
YAJIMA KAZUYOSHI (JP)
International Classes:
C07K17/00; C12N1/21; C12N15/31; C12P21/02; (IPC1-7): C12N15/31; C07K17/00; C12N1/21; C12P21/02
Foreign References:
| JPS59113890A | 1984-06-30 | |||
| JPS59205996A | 1984-11-21 | |||
| JPS6058074A | 1985-04-04 | |||
| JPH03251185A | 1991-11-08 | |||
| JPH04278091A | 1992-10-02 | |||
| JPH06296485A | 1994-10-25 | |||
| JPH07265094A | 1995-10-17 |
Other References:
UHLEN M. ET AL: "Complete sequence of the staphylococcal gene encoding protein A. A gene evolved through multiple duplications", J.BIOL.CHEM., vol. 259, no. 3, 1984, pages 1695 - 1702, XP008092291
LOFDAHL S. ET AL: "Gene for staphylococcal protein A", PROC.NATL.ACAD.SCI. USA, vol. 80, no. 3, 1983, pages 697 - 701, XP008095034
UDAKA J. ET AL: "Ishu Tanpakushitsu no Seisan Gijutsu Bacillus brevis ni yoru Seisan o Chushin ni", BIO INDUSTRY, vol. 9, no. 2, 1992, pages 23 - 31, XP008092297
See also references of EP 1767640A4
LOFDAHL S. ET AL: "Gene for staphylococcal protein A", PROC.NATL.ACAD.SCI. USA, vol. 80, no. 3, 1983, pages 697 - 701, XP008095034
UDAKA J. ET AL: "Ishu Tanpakushitsu no Seisan Gijutsu Bacillus brevis ni yoru Seisan o Chushin ni", BIO INDUSTRY, vol. 9, no. 2, 1992, pages 23 - 31, XP008092297
See also references of EP 1767640A4
Attorney, Agent or Firm:
KANEKA CORPORATION (Kita-ku Osaka-shi, Osaka 88, JP)
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