PROCESS FOR PRODUCING QUINAZOLINE DERIVATIVE OR SALT THEREOF

Title:

PROCESS FOR PRODUCING QUINAZOLINE DERIVATIVE OR SALT THEREOF

Document Type and Number:

WIPO Patent Application WO/2000/053584

Kind Code:

A1

Abstract:

A process for producing a quinazoline derivative represented by general formula (I) which comprises reacting a compound represented by general formula (II) with a compound represented by R?3¿-X (III) in an appropriate solvent in the presence of an alkali metal carbonate and optionally of a small amount of water. In the formulas, R?1¿ represents hydrogen or halogeno; R?2¿ represents protected carboxy; R?3¿ represents ar(lower)alkyl optionally substituted by one or more appropriate substituents; Z represents lower alkylene; and X represents an acid residue.

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Inventors:

FUKAGAWA MASAYASU (JP)
IEDA SHIGERU (JP)
TSUBOI HIROYUKI (JP)
GOTO SHUNSUKE (JP)
KAGARA KOOJI (JP)
UEMATSU RYOICHI (JP)
NISIWAKI MASANORI (JP)

Application Number:

PCT/JP2000/001360

Publication Date:

September 14, 2000

Filing Date:

March 06, 2000

Export Citation:

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Assignee:

FUJISAWA PHARMACEUTICAL CO (JP)
FUKAGAWA MASAYASU (JP)
IEDA SHIGERU (JP)
TSUBOI HIROYUKI (JP)
GOTO SHUNSUKE (JP)
KAGARA KOOJI (JP)
UEMATSU RYOICHI (JP)
NISIWAKI MASANORI (JP)

International Classes:

C07D239/96; C07D; (IPC1-7): C07D239/96

Foreign References:

EP0218999A2	1987-04-22
JPS6425767A	1989-01-27

Other References:

GOTO S. ET. AL.: "A convenient synthesis of 1-substituted-2,4 (1H,3H) Quinozolinedione: industrial synthesis of zenarestat", CHEMISTRY EXPRESS (KINKI CHEMICAL SOCIETY, JAPAN), vol. 8, no. 9, 1993, pages 761 - 764, XP002928777
M. S. MALAMAS ET. AL.: "Quinazolineacetic Acid and Related Analogues as Aldose Reductase Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 34, no. 4, 1991, pages 1492 - 1503, XP002928778
See also references of EP 1160243A4

Attorney, Agent or Firm:

Tabushi, Eiji (Ltd.Osaka Factory 1-6 Kashima 2-chome Yodogawa-ku, Osaka-shi Osaka, JP)

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