PROCESS FOR PRODUCING XANTHINE DERIVATIVE

WIPO Patent Application WO/1995/031460

A1

A process for converting a xanthine derivative represented by general formula (I) [compound (I)], (wherein R1 and R2 are the same or different from each other and each represents hydrogen or hydroxy-, oxo- or unsubstituted lower alkyl) into another xanthine derivative represented by general formula (II) [compound (II)], (wherein R3 and R4 are the same or different from each other and each represents hydrogen or hydroxy-, oxo- or unsubstituted lower alkyl; R5 and R6 are the same or different from each other and each represents hydrogen, hydroxy or oxo, provided when both of R5 and R6 are hydrogen, at least one of R3 and R4 is hydroxy- or oxo-substituted lower alkyl; and X and Y represent both hydrogen or they are combined together to represent a single bond) in the presence of an enzyme source which catalyzes the hydroxylation or carbonylation of compound (I) into compound (II).

JPH07503486	[Title of Invention] Substituted Aminoalkyl Compound
WO/2005/085246	8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINE, THE PRODUCTION THEREOF AND THE USE IN THE FORM OF A DPP INHIBITOR
JPH05105631	ANTIDEMENTIAL AGENT

SHIMADA JUNICHI (JP)
EGUCHI TAMOTSU (JP)
MOCHIDA KENICHI (JP)
HORIGUCHI AKIRA (JP)
YASUZAWA TOHRU (JP)
KUSAKA HIDEAKI (US)
NONAKA HIROMI (JP)
SUZUKI FUMIO (JP)

PCT/JP1995/000929

November 23, 1995

May 16, 1995

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KYOWA HAKKO KOGYO KK (JP)
SHIMADA JUNICHI (JP)
EGUCHI TAMOTSU (JP)
MOCHIDA KENICHI (JP)
HORIGUCHI AKIRA (JP)
YASUZAWA TOHRU (JP)
KUSAKA HIDEAKI (US)
NONAKA HIROMI (JP)
SUZUKI FUMIO (JP)

C07D473/04; C07D473/06; C12P17/18; (IPC1-7): C07D473/04; C12P17/18

JPH03173889A	1991-07-29
JPH04270222A	1992-09-25
JPH0558913A	1993-03-09

See also references of EP 0711772A4

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