Title:
PROCESS FOR THE PRODUCTION OF L-LYSINE USING CORYNEFORM BACTERIA
Document Type and Number:
WIPO Patent Application WO2004013340
Kind Code:
A3
Abstract:
The invention relates to a process for the production of L-lysine, in which the following steps are carried out a) fermentation of the L-lysine producing coryneform bacteria that are at least sensitive to diaminopimelic acid analogues, in particular 4-hydroxydiaminopimelic acid; b) enrichment of the L-lysine in the medium or in the bacterial cells; and optionally c) isolation of the L-lysine or L-lysine-containing feedstuffs additive from the fermentation broth, so that >= 0 to 100% of the constituents from the fermentation broth and/or from the biomass are present, and optionally bacteria are used in which in addition further genes of the biosynthesis pathway of L-lysine are enhanced, or bacteria are used in which the metabolic pathways that reduce the formation of L-lysine are at least partially switched off.
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Inventors:
BATHE BRIGITTE
REYNEN CAROLINE
PFEFFERLE WALTER
REYNEN CAROLINE
PFEFFERLE WALTER
Application Number:
PCT/EP2003/007475
Publication Date:
March 25, 2004
Filing Date:
July 10, 2003
Export Citation:
Assignee:
DEGUSSA (DE)
International Classes:
A23K1/00; A23K1/16; C12P13/08; (IPC1-7): C12P13/08; A23K1/00; C07C229/26; C12N1/20
Foreign References:
| EP0510319A2 | 1992-10-28 |
Other References:
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; COUDERT, MICHELE ET AL: "Obtainment of regulation mutants for the lysine biosynthetic pathway in a Corynebacterium strain resistant to lysine analogs", XP002267565, retrieved from STN Database accession no. 80:105697
SAHM H ET AL: "CONSTRUCTION OF L-LYSINE, L-THREONINE-, OR L-ISOLEUCINE-OVERPRODUCING STRAINS OF CORYNEBACTERIUM GLUTAMICUM", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, NEW YORK ACADEMY OF SCIENCES, NEW YORK, NY, US, vol. 782, 1996, pages 25 - 39, XP000943151, ISSN: 0077-8923
SIMMONDS D H: "ANALOGS OF DIAMINOPIMELIC ACID AS INHIBITORS OF BACTERIAL GRWOTH", BIOCHEMICAL JOURNAL, PORTLAND PRESS, LONDON, GB, vol. 58, 1954, pages 520 - 523, XP008025012, ISSN: 0264-6021
SAHM H ET AL: "CONSTRUCTION OF L-LYSINE, L-THREONINE-, OR L-ISOLEUCINE-OVERPRODUCING STRAINS OF CORYNEBACTERIUM GLUTAMICUM", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, NEW YORK ACADEMY OF SCIENCES, NEW YORK, NY, US, vol. 782, 1996, pages 25 - 39, XP000943151, ISSN: 0077-8923
SIMMONDS D H: "ANALOGS OF DIAMINOPIMELIC ACID AS INHIBITORS OF BACTERIAL GRWOTH", BIOCHEMICAL JOURNAL, PORTLAND PRESS, LONDON, GB, vol. 58, 1954, pages 520 - 523, XP008025012, ISSN: 0264-6021
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