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Title:
PROCESS FOR SYNTHESIZING ASPARTIC AND GLUTAMIC ACID DERIVATIVES AND DIAZOKETONE INTERMEDIATES THEREOF
Document Type and Number:
WIPO Patent Application WO2003042169
Kind Code:
A3
Abstract:
The invention relates to novel diazoketone derivatives represented by formula 1. Wherein R<1>, R, R, R<5> n and p have the meanings given in the application. The invention also relates to processes for homologation of these diazoketone derivatives. The processes are useful for preparing compounds that are caspase inhibitors.

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Inventors:
MORTIMORE MICHAEL
PHILPS OLIVER
STUDLEY JOHN
Application Number:
PCT/US2002/032218
Publication Date:
April 01, 2004
Filing Date:
October 08, 2002
Export Citation:
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Assignee:
VERTEX PHARMA (US)
International Classes:
C07C227/32; C07C229/24; C07F7/18; C07C245/00; C07C245/04; C07C245/18; (IPC1-7): C07C245/18; C07C227/32
Foreign References:
GB1374491A1974-11-20
JP2000290202A2000-10-17
Other References:
GOBULEV A. ET AL.: "An Efficient Synthesis of 5-Hydroxy-4-oxo-L-norvaline from L-Aspartic Acid", TETRAHEDRON LETTERS, vol. 34, no. 37, 1993, pages 5879 - 5880, XP009004200
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