PROCESSES FOR THE SYNTHESIS OF LEVOCETIRIZINE AND INTERMEDIATES FOR USE THEREIN

Title:

PROCESSES FOR THE SYNTHESIS OF LEVOCETIRIZINE AND INTERMEDIATES FOR USE THEREIN

Document Type and Number:

WIPO Patent Application WO/2009/147389

Kind Code:

A8

Abstract:

The present invention provides a compound of formula (IV) wherein R is Cl, Br, NO2, OH or OR', and R' is alkyl, and its use in the synthesis of levocetirizine, including its use in the synthesis of (-)-1-[(4-chlorophenyl)-phenyl methyl] piperazine, an intermediate useful in the synthesis of levocetirizine. The present invention also provides compounds (II) and (III) which are useful in the synthesis of compound (IV).

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Inventors:

RAO DHARMARAJ RAMACHANDRA (IN)
KANKAN RAJENDRA NARAYANRAO (IN)
GHAGARE MARUTI (IN)
CHIKHALIKAR SANDIP VASANT (IN)

Application Number:

PCT/GB2009/001385

Publication Date:

December 23, 2010

Filing Date:

June 02, 2009

Export Citation:

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Assignee:

CIPLA LTD (IN)
RAO DHARMARAJ RAMACHANDRA (IN)
KANKAN RAJENDRA NARAYANRAO (IN)
GHAGARE MARUTI (IN)
CHIKHALIKAR SANDIP VASANT (IN)
CURTIS PHILIP ANTHONY (GB)

International Classes:

C07D295/088; C07C27/00; C07D295/073; C07D295/096

Attorney, Agent or Firm:

COTTRILL, Emily, Elizabeth, Helen et al. (235 High Holborn, London WCW 7LE, GB)

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