Title:
PRODUCTION OF GALACTOSYLATED GLYCOPROTEINS IN LOWER EUKARYOTES
Document Type and Number:
WIPO Patent Application WO2005100584
Kind Code:
A3
Abstract:
The present invention provides a novel lower eukaryotic host cell producing human-like glycoproteins characterized as having a terminal ß-galactose residue and essentially lacking fucose and sialic acid residues. The present invention also provides a method for catalyzing the transfer of a galactose residue from UDP-galactose onto an acceptor substrate in a recombinant lower eukaryotic host cell, which can be used as a therapeutic glycoprotein.
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Inventors:
DAVIDSON ROBERT (US)
GERNGROSS TILLMAN (US)
WILDT STEFAN (US)
CHOI BYUNG-KWON (US)
NETT JUERGEN (US)
BOBROWICZ PIOTR (US)
HAMILTON STEPHEN (US)
GERNGROSS TILLMAN (US)
WILDT STEFAN (US)
CHOI BYUNG-KWON (US)
NETT JUERGEN (US)
BOBROWICZ PIOTR (US)
HAMILTON STEPHEN (US)
Application Number:
PCT/IB2005/051249
Publication Date:
December 21, 2006
Filing Date:
April 15, 2005
Export Citation:
Assignee:
GLYCOFI INC (US)
DAVIDSON ROBERT (US)
GERNGROSS TILLMAN (US)
WILDT STEFAN (US)
CHOI BYUNG-KWON (US)
NETT JUERGEN (US)
BOBROWICZ PIOTR (US)
HAMILTON STEPHEN (US)
DAVIDSON ROBERT (US)
GERNGROSS TILLMAN (US)
WILDT STEFAN (US)
CHOI BYUNG-KWON (US)
NETT JUERGEN (US)
BOBROWICZ PIOTR (US)
HAMILTON STEPHEN (US)
International Classes:
C12N1/19; C07K16/00; C12N1/18; C12N9/10; C12N9/90; C12P21/00; C12P21/06
Other References:
CHOI B.W. ET AL.: "Use of Combinational genetic libraries to humanize N-linked glycosylation in the yeast Pichia pastoris", PNAS, vol. 100, no. 9, April 2003 (2003-04-01), pages 5022 - 5027, XP002267831
See also references of EP 1737969A4
See also references of EP 1737969A4
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