Title:
PRODUCTION METHOD FOR FORMULATION COMPOSITION, AND PRODUCTION METHOD FOR FORMULATION
Document Type and Number:
WIPO Patent Application WO/2023/145871
Kind Code:
A1
Abstract:
Provided are: a production method for a formulation composition from which it is possible to easily obtain a formulation that has a high hardness and excellent granulation properties while inhibiting degradation of a drug during production; and a production method for the formulation. A production method for a formulation composition according to the present invention comprises step 1 for kneading and granulating, in a barrel, a mixture containing a filler, an active component, and a binding agent by twin-screw extrusion. The temperature in the barrel is at most 140°C. The mass-average molecular weight of the binding agent is at most 1,000,000 g/mol. The proportion of the filler and the active component contained in the mixture is 80-95 mass% with respect to the total mass of the filler, the active component, and the binding agent. The proportion of the filler contained in the mixture is 1-94 mass% with respect to the total mass of the filler, the active component, and the binding agent.
Inventors:
FUJISAKI MOTOHARU (JP)
KIMURA AKIRA (JP)
KIMURA AKIRA (JP)
Application Number:
PCT/JP2023/002614
Publication Date:
August 03, 2023
Filing Date:
January 27, 2023
Export Citation:
Assignee:
SUMITOMO SEIKA CHEMICALS (JP)
International Classes:
A61K9/20; A61K31/167; A61K45/00; A61K47/32; A61K47/34; A61K47/38
Domestic Patent References:
| WO2007072908A1 | 2007-06-28 |
Foreign References:
| JP2016511223A | 2016-04-14 | |||
| JP2015500273A | 2015-01-05 | |||
| JP2004524300A | 2004-08-12 | |||
| JP2008540540A | 2008-11-20 | |||
| JP2018507180A | 2018-03-15 |
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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