Title:
PRODUCTION METHOD FOR KIDNEY-DERIVED SOMATIC STEM CELLS
Document Type and Number:
WIPO Patent Application WO/2014/038653
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a method and the like for efficiently growing kidney-derived somatic stem cells. This production method for kidney-derived somatic stem cells comprises the following steps (A) and (B): a step (A) in which a group of cells including cells that constitute the kidneys are made to pass through the G0 phase or the G1 phase, and a gene for a protein that is active in causing the transition to the S phase are expressed; and a step (B) in which the cells obtained at the step (A) are cultivated in the presence of an extracellular growth factor.
Inventors:
HIJIKATA MAKOTO (JP)
YAMAGUCHI TATSUYA (JP)
YAMAGUCHI TATSUYA (JP)
Application Number:
PCT/JP2013/074028
Publication Date:
March 13, 2014
Filing Date:
September 06, 2013
Export Citation:
Assignee:
UNIV KYOTO (JP)
TOYO BOSEKI (JP)
TOYO BOSEKI (JP)
International Classes:
C12N5/10; A61K31/7088; A61K35/22; A61K35/23; A61K48/00; A61P13/12; C12M1/00
Domestic Patent References:
| WO2004047747A2 | 2004-06-10 | |||
| WO2002095026A1 | 2002-11-28 | |||
| WO2012133156A1 | 2012-10-04 |
Foreign References:
| JP2009535024A | 2009-10-01 | |||
| JP2005520516A | 2005-07-14 |
Other References:
ARTEGIANI BENEDETTA ET AL.: "Overexpression of cdk4 and cyclinDl triggers greater expansion of neural stem cells in the adult mouse brain", J. EXP. MED., vol. 208, no. 5, 2011, pages 937 - 948
BECKER A. KLAUS ET AL.: "Self-renewal of human embryonic stem cells is supported by a shortened Gl cell cycle phase", J. CELL. PHYSIOL., vol. 209, no. 3, 2006, pages 883 - 893
BECKER A. KLAUS ET AL.: "Cyclin D2 and the CDK substrate p220(NPAT) are required for self-renewal of human embryonic stem cells", J. CELL. PHYSIOL., vol. 222, 2010, pages 456 - 464
LIM SHUHUI ET AL.: "Loss of Cdk2 and Cdk4 Induces a Switch from Proliferation to Differentiation in Neural Stem Cells", STEM CELLS, vol. 30, April 2012 (2012-04-01), pages 1509 - 1520
HIDEO EMA ET AL.: "Zoketsu Kansaibo no Saikin no Shinpo - Zoketsu Kansaibo no Jiko Fukusei to Saibo Shuki", REGENERATIVE MEDICINE, 2006, pages 71 - 78
BECKER A. KLAUS ET AL.: "Self-renewal of human embryonic stem cells is supported by a shortened Gl cell cycle phase", J. CELL. PHYSIOL., vol. 209, no. 3, 2006, pages 883 - 893
BECKER A. KLAUS ET AL.: "Cyclin D2 and the CDK substrate p220(NPAT) are required for self-renewal of human embryonic stem cells", J. CELL. PHYSIOL., vol. 222, 2010, pages 456 - 464
LIM SHUHUI ET AL.: "Loss of Cdk2 and Cdk4 Induces a Switch from Proliferation to Differentiation in Neural Stem Cells", STEM CELLS, vol. 30, April 2012 (2012-04-01), pages 1509 - 1520
HIDEO EMA ET AL.: "Zoketsu Kansaibo no Saikin no Shinpo - Zoketsu Kansaibo no Jiko Fukusei to Saibo Shuki", REGENERATIVE MEDICINE, 2006, pages 71 - 78
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
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