Title:
PROPHYLACTIC DRUG AND THERAPEUTIC DRUG FOR DIABETES-ASSOCIATED DEMENTIA
Document Type and Number:
WIPO Patent Application WO/2023/248374
Kind Code:
A1
Abstract:
It is considered that diabetes-associated dementia is mainly caused by insulin resistance and relative insulin deficiency in the brain. Meanwhile, delivery of drugs to the brain is inhibited by the blood-brain barrier, and therefore, there has been so far no drug that provides excellent drug delivery to the brain. Therefore, there has been no wonder drug for diabetes-associated dementia. LPSs have a high molecular weight and therefore do not pass through the blood-brain barrier. A prophylactic drug or therapeutic drug for diabetes-associated dementia according to the present invention is characterized by containing a lipopolysaccharide as an active ingredient. According to the present invention, it is possible to provide a composition for a drug, food, or the like that has the effect of preventing and treating impairment due to diabetes-associated dementia, by means of a lipopolysaccharide derived from a bacterium belonging to the genus Pantoea. A lipopolysaccharide derived from a bacterium belonging to the family Enterobacteriaceae is confirmed to be safe when used for oral or transdermal administration in the form of food, cosmetics, feed, or the like, and thus can be expected to provide prophylactic and therapeutic effects with a low risk of side effects.
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Inventors:
SOMA GEN-ICHIRO (JP)
INAGAWA HIROYUKI (JP)
KOHCHI CHIE (JP)
MIZOBUCHI HARUKA (JP)
INAGAWA HIROYUKI (JP)
KOHCHI CHIE (JP)
MIZOBUCHI HARUKA (JP)
Application Number:
PCT/JP2022/024854
Publication Date:
December 28, 2023
Filing Date:
June 22, 2022
Export Citation:
Assignee:
SOMA GENICHIRO (JP)
BIOMEDICAL RES GROUP INC (JP)
BIOMEDICAL RES GROUP INC (JP)
International Classes:
A61K31/739; A61K35/741; A61P3/10; A61P25/28
Domestic Patent References:
| WO2005030938A1 | 2005-04-07 |
Other References:
溝渕悠代ほか, LPS経口投与によるstreptozotocin誘発糖尿病マウスにおける認知障害の予防効果, 第24回バイオ治療法研究会学術集会プログラム・抄録集, 2020, p. 37, general subject 4-1 lines 11-23, 33-35, (MIZOBUCHI, Haruka et al.), non-official translation (Preventive effect of oral administration of LPS on cognitive impairment in streptozotocin-induced diabetic mice. Programs and Abstracts of the 24th Annual Meeting of the Society of Biotherapeutic Approaches.)
MIZOBUCHI HARUKA, YAMAMOTO KAZUSHI, YAMASHITA MASASHI, INAGAWA HIROYUKI, KOHCHI CHIE, SOMA GEN-ICHIRO: "Oral Administration of Lipopolysaccharide Prevents Cognitive Impairment in Streptozotocin-induced Diabetic Mice in a Blood Glucose-independent Manner", ANTICANCER RESEARCH, INTERNATIONAL INSTITUTE OF ANTICANCER RESEARCH, GR, vol. 41, no. 8, 1 August 2021 (2021-08-01), GR , pages 4053 - 4059, XP093121129, ISSN: 0250-7005, DOI: 10.21873/anticanres.15206
MIZOBUCHI HARUKA, YAMAMOTO KAZUSHI, YAMASHITA MASASHI, NAKATA YOKO, INAGAWA HIROYUKI, KOHCHI CHIE, SOMA GEN-ICHIRO: "Prevention of Diabetes-Associated Cognitive Dysfunction Through Oral Administration of Lipopolysaccharide Derived From Pantoea agglomerans", FRONTIERS IN IMMUNOLOGY, FRONTIERS MEDIA, LAUSANNE, CH, vol. 12, 27 August 2021 (2021-08-27), Lausanne, CH , pages 650176, XP093121131, ISSN: 1664-3224, DOI: 10.3389/fimmu.2021.650176
MIZOBUCHI HARUKA, YAMAMOTO KAZUSHI, YAMASHITA MASASHI, INAGAWA HIROYUKI, KOHCHI CHIE, SOMA GEN-ICHIRO: "Oral Administration of Lipopolysaccharide Prevents Cognitive Impairment in Streptozotocin-induced Diabetic Mice in a Blood Glucose-independent Manner", ANTICANCER RESEARCH, INTERNATIONAL INSTITUTE OF ANTICANCER RESEARCH, GR, vol. 41, no. 8, 1 August 2021 (2021-08-01), GR , pages 4053 - 4059, XP093121129, ISSN: 0250-7005, DOI: 10.21873/anticanres.15206
MIZOBUCHI HARUKA, YAMAMOTO KAZUSHI, YAMASHITA MASASHI, NAKATA YOKO, INAGAWA HIROYUKI, KOHCHI CHIE, SOMA GEN-ICHIRO: "Prevention of Diabetes-Associated Cognitive Dysfunction Through Oral Administration of Lipopolysaccharide Derived From Pantoea agglomerans", FRONTIERS IN IMMUNOLOGY, FRONTIERS MEDIA, LAUSANNE, CH, vol. 12, 27 August 2021 (2021-08-27), Lausanne, CH , pages 650176, XP093121131, ISSN: 1664-3224, DOI: 10.3389/fimmu.2021.650176
Attorney, Agent or Firm:
NAKAMURA Kazuo (JP)
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