Title:
PROPHYLACTIC OR THERAPEUTIC AGENT FOR CEREBRAL ISCHEMIA OR CEREBRAL ISCHEMIC REPERFUSION INJURY IN STROKE
Document Type and Number:
WIPO Patent Application WO/2007/097301
Kind Code:
A1
Abstract:
Disclosed is a prophylactic or therapeutic agent for cerebral ischemia injury or cerebral ischemic reperfusion injury occurring in stroke such as cerebral infarction or cerebral hemorrhage, which develops its efficacy through a mechanism different from those of conventional ones and can be administered over a long period. The prophylactic or therapeutic agent comprises 6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2- carboxamide as an active ingredient. Particularly preferably, the compound is fidarestat, which is an optically resolved form having a (2S,4S) configuration.
Inventors:
CHUNG SOOKJA KIM (CN)
CHUNG STEPHEN (CN)
HIBI CHIHIRO (JP)
CHUNG STEPHEN (CN)
HIBI CHIHIRO (JP)
Application Number:
PCT/JP2007/053036
Publication Date:
August 30, 2007
Filing Date:
February 20, 2007
Export Citation:
Assignee:
SANWA KAGAKU KENKYUSHO CO (JP)
CHUNG SOOKJA KIM (CN)
CHUNG STEPHEN (CN)
HIBI CHIHIRO (JP)
CHUNG SOOKJA KIM (CN)
CHUNG STEPHEN (CN)
HIBI CHIHIRO (JP)
International Classes:
A61K31/4188; A61P7/02; A61P9/10; C07D491/107
Domestic Patent References:
| WO2006090699A1 | 2006-08-31 | |||
| WO2002098462A1 | 2002-12-12 |
Foreign References:
| JPH09316003A | 1997-12-09 | |||
| JPH04173791A | 1992-06-22 | |||
| JP2002370984A | 2002-12-24 |
Other References:
See also references of EP 1987829A4
Attorney, Agent or Firm:
HIROE, Takenori et al. (Gifu-shi Gifu, 68, JP)
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