Title:
PROPHYLACTIC OR THERAPEUTIC AGENT FOR VIRUS INFECTIOUS DISEASE
Document Type and Number:
WIPO Patent Application WO/2013/065690
Kind Code:
A1
Abstract:
The present invention provides a prophylactic or therapeutic agent for a virus infectious disease, in particular a prophylactic or therapeutic agent for an enveloped virus infectious disease, said agent comprising a γ-interferon-inducible lysosomal thiol reductase expression vector or a γ-interferon-inducible lysosomal thiol reductase mimic.
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Inventors:
KUBO YOSHINAO (JP)
KAMIYAMA HARUKA (JP)
KAKOKI KATSURA (JP)
HAYASHI HIDEKI (JP)
MATSUYAMA TOSHIFUMI (JP)
KAMIYAMA HARUKA (JP)
KAKOKI KATSURA (JP)
HAYASHI HIDEKI (JP)
MATSUYAMA TOSHIFUMI (JP)
Application Number:
PCT/JP2012/078053
Publication Date:
May 10, 2013
Filing Date:
October 30, 2012
Export Citation:
Assignee:
UNIV NAGASAKI (JP)
International Classes:
A61K45/00; A61K31/095; A61K31/428; A61K31/4406; A61K31/505; A61K35/76; A61K38/44; A61K48/00; A61P31/12; A61P31/14; A61P31/18; C12N9/02; C12N15/09
Other References:
TOPOL IA ET AL.: "Experimental determination and calculations of redox potential descriptors of compounds directed against retroviral zinc fingers: Implications for rational drug design", PROTEIN SCI., vol. 10, no. 7, July 2001 (2001-07-01), pages 1434 - 1445, XP055067720
SINGH R ET AL.: "GILT is a critical host factor for Listeria monocytogenes infection", NATURE, vol. 455, no. 7217, 30 October 2008 (2008-10-30), pages 1244 - 1247, XP055067721
OU W ET AL.: "Role of protein disulfide isomerase and other thiol-reactive proteins in HIV-1 envelope protein-mediated fusion", VIROLOGY, vol. 350, no. 2, 28 February 2006 (2006-02-28), pages 406 - 417, XP005507930
ARUNACHALAM B ET AL.: "Enzymatic reduction of disulfide bonds in lysosomes: characterization of a gamma-interferon-inducible lysosomal thiol reductase (GILT)", PROC NATL ACAD SCI U S A, vol. 97, no. 2, 18 January 2000 (2000-01-18), pages 745 - 750, XP002377073
JAIN S ET AL.: "Thiol/disulfide exchange is required for membrane fusion directed by the Newcastle disease virus fusion protein", J VIROL., vol. 81, no. 5, 6 December 2006 (2006-12-06), pages 2328 - 2339, XP055067737
SINGH R ET AL.: "GILT is a critical host factor for Listeria monocytogenes infection", NATURE, vol. 455, no. 7217, 30 October 2008 (2008-10-30), pages 1244 - 1247, XP055067721
OU W ET AL.: "Role of protein disulfide isomerase and other thiol-reactive proteins in HIV-1 envelope protein-mediated fusion", VIROLOGY, vol. 350, no. 2, 28 February 2006 (2006-02-28), pages 406 - 417, XP005507930
ARUNACHALAM B ET AL.: "Enzymatic reduction of disulfide bonds in lysosomes: characterization of a gamma-interferon-inducible lysosomal thiol reductase (GILT)", PROC NATL ACAD SCI U S A, vol. 97, no. 2, 18 January 2000 (2000-01-18), pages 745 - 750, XP002377073
JAIN S ET AL.: "Thiol/disulfide exchange is required for membrane fusion directed by the Newcastle disease virus fusion protein", J VIROL., vol. 81, no. 5, 6 December 2006 (2006-12-06), pages 2328 - 2339, XP055067737
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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