Title:
PROSTHETIC HEART VALVE AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2022/057841
Kind Code:
A1
Abstract:
A prosthetic heart valve and a preparation method therefor, the preparation method being as follows: cross-linking heterogeneous biological tissues by means of in-situ copolymerisation, compounding same with a hydrogel, and suitably dehydrating the obtained biological tissue to obtain dry biological tissue; the biological tissue has strong mechanical strength and tear resistance in a wet state and good elasticity and flexibility in a dry state, will not produce permanent deformation under long-term stress conditions, and can recover the original shape when placed in water, and can therefore be pre-mounted in a dry state on a valve delivery system during production, reducing the production and transportation costs of traditional interventional biological valves and shortening the surgery time. Also, the aldehyde-based residue caused by the cross-linking of glutaraldehyde in conventional interventional biological valves is avoided, the anti-calcification performance of the valve is improved and blood compatibility is enhanced, and the service life of the valve is prolonged.
Inventors:
ZHOU ZHONGYI (CN)
XU LIANGPENG (CN)
WANG YUNBING (CN)
GUO GAOYANG (CN)
HE HAIYANG (CN)
LEI YANG (CN)
XU LIANGPENG (CN)
WANG YUNBING (CN)
GUO GAOYANG (CN)
HE HAIYANG (CN)
LEI YANG (CN)
Application Number:
PCT/CN2021/118617
Publication Date:
March 24, 2022
Filing Date:
September 15, 2021
Export Citation:
Assignee:
JILIN VENUS HAOYUE MEDICAL LTD (CN)
International Classes:
A61L27/50; A61L27/36; A61L27/52; C08F222/38; C08J3/075; C08L35/00
Foreign References:
| CN109833519A | 2019-06-04 | |||
| CN110655621A | 2020-01-07 | |||
| CN110885524A | 2020-03-17 | |||
| US20190030212A1 | 2019-01-31 | |||
| CN112220971A | 2021-01-15 |
Other References:
FENG ZHANBIN, ZUO HONGLI, HU JING, GAO WEISHENG, YU BING, NING NANYING, TIAN MING, ZHANG LIQUN: "Mussel-Inspired Highly Stretchable, Tough Nanocomposite Hydrogel with Self-Healable and Near-Infrared Actuated Performance", INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, AMERICAN CHEMICAL SOCIETY, vol. 59, no. 1, 8 January 2020 (2020-01-08), pages 166 - 174, XP055912389, ISSN: 0888-5885, DOI: 10.1021/acs.iecr.9b04521
Attorney, Agent or Firm:
SHINY INTELLECTUAL PROPERTY FIRM (CN)
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