Title:
PROTEIN COMPRISING TRUNCATED FORM OF EXTRACELLULAR DOMAIN PROTEIN OF FRIZZLED 2, AND PHARMACEUTICAL COMPOSITION FOR TREATING BONE DISEASES WHICH COMPRISES SAID PROTEIN
Document Type and Number:
WIPO Patent Application WO/2012/176853
Kind Code:
A1
Abstract:
The present invention provides: a protein comprising a truncated form of an extracellular domain protein of Frizzled 2, which has a higher secretion activity than that of a known protein comprising an extracellular cysteine-rich domain of Frizzled 2 in a cell that is producing the protein and also has a bone-mass-increasing activity equivalent to or higher than that of the known protein; or DNA encoding the protein.
Inventors:
KAKITANI MAKOTO
YAMAWAKI KENGO
YAMAWAKI KENGO
Application Number:
PCT/JP2012/065911
Publication Date:
December 27, 2012
Filing Date:
June 21, 2012
Export Citation:
Assignee:
KYOWA HAKKO KIRIN CO LTD (JP)
KAKITANI MAKOTO
YAMAWAKI KENGO
KAKITANI MAKOTO
YAMAWAKI KENGO
International Classes:
C12N15/09; A61K31/711; A61K38/00; A61K48/00; A61P19/08; A61P19/10; C07K14/705; C07K19/00
Domestic Patent References:
| WO2010038756A1 | 2010-04-08 | |||
| WO2008061013A2 | 2008-05-22 | |||
| WO2008031009A2 | 2008-03-13 | |||
| WO2010038756A1 | 2010-04-08 |
Foreign References:
| JP2004031385A | 2004-01-29 | |||
| JP2007295860A | 2007-11-15 |
Other References:
TOSTESON, A.N. ET AL., OSTEOPOROS INT., vol. 12, 2001, pages 1042 - 1049
YOH, K. ET AL., J. BONE MINER. METAB., vol. 23, 2005, pages 167 - 173
NGUYEN, N.D. ET AL., J. BONE MINER. RES., vol. 22, 2007, pages 1147 - 1154
MURAKI, S. ET AL., J. BONE MINER. METAB., vol. 24, 2006, pages 100 - 104
"Committee for preparing guidelines for prevention and treatment of osteoporosis, Guidelines for prevention and treatment of osteoporosis", LIFE SCIENCE (JAPAN, 2006
NAMPEI, A.; HASHIMOTO, J., THE BONE, vol. 22, no. 3, 2008, pages 109 - 113
SOEN, S., THE BONE, vol. 22, no. 3, 2008, pages 103 - 107
TAKAHASHI, S., THE BONE, vol. 22, no. 3, 2008, pages 115 - 120
DAUGIRDAS, J.T. ET AL.: "Clinical dialysis handbook 4rd edition,", 2009, MEDICAL SCIENCE INTERNATIONAL (JAPAN
AYUKO FUJIU ET AL.: "Clinical dialysis", vol. 24, 2008, JAPAN MEDICAL CENTER (JAPAN, pages: 43 - 50
COHEN, M.M. JR., AMERICAN J. MED. GENETICS, PART A, vol. 140A, 2006, pages 2646 - 2706
KOUSTENI, S. ET AL., CELL, vol. 104, 2001, pages 719 - 730
NAKAMURA, T. ET AL., CELL, vol. 130, 2007, pages 811 - 823
WADA, S. ET AL., MEBIO, vol. 25, no. 8, 2008, pages 89 - 95
WADA, S.; YASUDA, S., CLIN. CALCIUM, vol. 11, no. 9, 2001, pages 1169 - 1175
NAKAMURA, T., THE BONE, vol. 22, no. 3, 2008, pages 147 - 151
SANNA, G. ET AL., ANN. ONCOL., vol. 16, 2005, pages 1207 - 1208
THEILL, L.E. ET AL., ANN. REV. IMMUNOL., vol. 20, 2002, pages 795 - 823
KONG, YY ET AL., NATURE, vol. 397, 1999, pages 315 - 323
DOUGALL, W.C. ET AL., GENES DEV., vol. 13, 1999, pages 2412 - 2424
ATSUSHI HORIUCHI, CLINICIAN, vol. 47, 2000, pages 401 - 404
DAROSZEWSKA, A.; RALSTON, S.H., NATURE CLINICAL PRACTICE RHEUMATOLOGY, vol. 2, 2006, pages 270 - 277
JANSSENS, K. ET AL., NATURE GENETICS, vol. 26, 2000, pages 273 - 275
TANG, Y ET AL., NATURE MEDICINE, vol. 15, 2009, pages 757 - 765
SATOSHI MORI, CLINICIAN, vol. 49, 2002, pages 621 - 626
TAMAI, K. ET AL., NATURE, vol. 407, 2000, pages 530 - 535
MASIAKOWSKI, P.; YANCOPOULOS, G.D., CURR. BIOL., vol. 8, 1998, pages R407
DANN, C.E. ET AL., NATURE, vol. 412, 2001, pages 86 - 90
RAWADI, G.; ROMAN-ROMAN, S., EXPERT OPIN. THER. TARGETS, vol. 9, no. 5, 2005, pages 1063 - 1077
SEMENOV, M. ET AL., J.B.C., vol. 280, no. 29, 2005, pages 26770 - 26775
LI, X. ET AL., J. BONE MINER. RES., vol. 23, 2008, pages 860 - 869
YACCOBY, S., BLOOD, vol. 109, 2007, pages 2106 - 2111
NAKANISHI, R. ET AL., J. BONE MINER. RES., vol. 21, 2006, pages 1713 - 1721
TREVANT, B. ET AL., J. CELL. PHYSIOL., vol. 217, 2008, pages 113 - 126
WANG, Y ET AL., J.B.C., vol. 271, no. 8, 1996, pages 4468 - 4476
HUANG, H-C.; KLEIN, P.S., GENOME BIOLOGY, vol. 5, no. 234, 2004, pages 1 - 7
WHEELER, G.N., CURRENT BIOLOGY, vol. 10, 2000, pages 849 - 852
MATSUMOTO, K. ET AL., DEV. BIOL., vol. 319, no. 2, 2008, pages 234 - 247
GREGORIEFF, A. ET AL., GASTROENTEROLOGY, vol. 129, 2005, pages 626 - 638
KATOH, M.; KATOH, M., INT. J. MOL. MED., vol. 19, 2007, pages 529 - 533
SAGARA, N. ET AL., B.B.R.C., vol. 252, 1998, pages 117 - 122
KEMP, C.R. ET AL., DEV. DYNANICS, vol. 236, 2007, pages 2011 - 2019
MERLE, P. ET AL., J. HEPATOL., vol. 43, no. 5, 2005, pages 854 - 862
VINCAN, E. ET AL., DIFFERENTIATION, vol. 73, 2005, pages 142 - 153
CHACON, M.A. ET AL., J. CELL PHYSIOL., vol. 217, 2008, pages 215 - 227
HOLCOMBE, R.F. ET AL., MOL. PATHOL., vol. 55, 2002, pages 220 - 226
MILOVANOVIC, T. ET AL., INT. J. ONCOLOGY, vol. 25, 2004, pages 1337 - 1342
"MGI Direct Data Submission", 2005, DELTAGEN, INC., article "NIH initiative supporting placement of Deltagen, Inc. mice into public repositories"
ALTSCHUL, S. F. ET AL., J. MOL. BIOL., vol. 15, 1990, pages 403 - 410
KARLIN, S.; ALTSCHUL S. F., PROC. NATL. ACAD. SCI. USA, vol. 87, 1990, pages 2264 - 2268
KUNKEL ET AL., PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 488 - 492
F. M. AUSUBEL ET AL.: "Short Protocols in Molecular Biology", 1995, JOHN WILEY & SONS
J. SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual, 2nd ed.,", 1989, COLD SPRING HARBOR LABORATORY PRESS
J.VIROL., vol. 67, 1993, pages 5911 - 5921
HUMAN GENE THERAPY, vol. 5, 1994, pages 717 - 729
GENE THERAPY, vol. 1, 1994, pages 51 - 58
HUMAN GENE THERAPY, vol. 5, 1994, pages 793 - 801
GENE THERAPY, vol. 1, 1994, pages 165 - 169
KAKEDA ET AL., GENE THER., vol. 12, 2005, pages 852 - 856
See also references of EP 2725101A4
YOH, K. ET AL., J. BONE MINER. METAB., vol. 23, 2005, pages 167 - 173
NGUYEN, N.D. ET AL., J. BONE MINER. RES., vol. 22, 2007, pages 1147 - 1154
MURAKI, S. ET AL., J. BONE MINER. METAB., vol. 24, 2006, pages 100 - 104
"Committee for preparing guidelines for prevention and treatment of osteoporosis, Guidelines for prevention and treatment of osteoporosis", LIFE SCIENCE (JAPAN, 2006
NAMPEI, A.; HASHIMOTO, J., THE BONE, vol. 22, no. 3, 2008, pages 109 - 113
SOEN, S., THE BONE, vol. 22, no. 3, 2008, pages 103 - 107
TAKAHASHI, S., THE BONE, vol. 22, no. 3, 2008, pages 115 - 120
DAUGIRDAS, J.T. ET AL.: "Clinical dialysis handbook 4rd edition,", 2009, MEDICAL SCIENCE INTERNATIONAL (JAPAN
AYUKO FUJIU ET AL.: "Clinical dialysis", vol. 24, 2008, JAPAN MEDICAL CENTER (JAPAN, pages: 43 - 50
COHEN, M.M. JR., AMERICAN J. MED. GENETICS, PART A, vol. 140A, 2006, pages 2646 - 2706
KOUSTENI, S. ET AL., CELL, vol. 104, 2001, pages 719 - 730
NAKAMURA, T. ET AL., CELL, vol. 130, 2007, pages 811 - 823
WADA, S. ET AL., MEBIO, vol. 25, no. 8, 2008, pages 89 - 95
WADA, S.; YASUDA, S., CLIN. CALCIUM, vol. 11, no. 9, 2001, pages 1169 - 1175
NAKAMURA, T., THE BONE, vol. 22, no. 3, 2008, pages 147 - 151
SANNA, G. ET AL., ANN. ONCOL., vol. 16, 2005, pages 1207 - 1208
THEILL, L.E. ET AL., ANN. REV. IMMUNOL., vol. 20, 2002, pages 795 - 823
KONG, YY ET AL., NATURE, vol. 397, 1999, pages 315 - 323
DOUGALL, W.C. ET AL., GENES DEV., vol. 13, 1999, pages 2412 - 2424
ATSUSHI HORIUCHI, CLINICIAN, vol. 47, 2000, pages 401 - 404
DAROSZEWSKA, A.; RALSTON, S.H., NATURE CLINICAL PRACTICE RHEUMATOLOGY, vol. 2, 2006, pages 270 - 277
JANSSENS, K. ET AL., NATURE GENETICS, vol. 26, 2000, pages 273 - 275
TANG, Y ET AL., NATURE MEDICINE, vol. 15, 2009, pages 757 - 765
SATOSHI MORI, CLINICIAN, vol. 49, 2002, pages 621 - 626
TAMAI, K. ET AL., NATURE, vol. 407, 2000, pages 530 - 535
MASIAKOWSKI, P.; YANCOPOULOS, G.D., CURR. BIOL., vol. 8, 1998, pages R407
DANN, C.E. ET AL., NATURE, vol. 412, 2001, pages 86 - 90
RAWADI, G.; ROMAN-ROMAN, S., EXPERT OPIN. THER. TARGETS, vol. 9, no. 5, 2005, pages 1063 - 1077
SEMENOV, M. ET AL., J.B.C., vol. 280, no. 29, 2005, pages 26770 - 26775
LI, X. ET AL., J. BONE MINER. RES., vol. 23, 2008, pages 860 - 869
YACCOBY, S., BLOOD, vol. 109, 2007, pages 2106 - 2111
NAKANISHI, R. ET AL., J. BONE MINER. RES., vol. 21, 2006, pages 1713 - 1721
TREVANT, B. ET AL., J. CELL. PHYSIOL., vol. 217, 2008, pages 113 - 126
WANG, Y ET AL., J.B.C., vol. 271, no. 8, 1996, pages 4468 - 4476
HUANG, H-C.; KLEIN, P.S., GENOME BIOLOGY, vol. 5, no. 234, 2004, pages 1 - 7
WHEELER, G.N., CURRENT BIOLOGY, vol. 10, 2000, pages 849 - 852
MATSUMOTO, K. ET AL., DEV. BIOL., vol. 319, no. 2, 2008, pages 234 - 247
GREGORIEFF, A. ET AL., GASTROENTEROLOGY, vol. 129, 2005, pages 626 - 638
KATOH, M.; KATOH, M., INT. J. MOL. MED., vol. 19, 2007, pages 529 - 533
SAGARA, N. ET AL., B.B.R.C., vol. 252, 1998, pages 117 - 122
KEMP, C.R. ET AL., DEV. DYNANICS, vol. 236, 2007, pages 2011 - 2019
MERLE, P. ET AL., J. HEPATOL., vol. 43, no. 5, 2005, pages 854 - 862
VINCAN, E. ET AL., DIFFERENTIATION, vol. 73, 2005, pages 142 - 153
CHACON, M.A. ET AL., J. CELL PHYSIOL., vol. 217, 2008, pages 215 - 227
HOLCOMBE, R.F. ET AL., MOL. PATHOL., vol. 55, 2002, pages 220 - 226
MILOVANOVIC, T. ET AL., INT. J. ONCOLOGY, vol. 25, 2004, pages 1337 - 1342
"MGI Direct Data Submission", 2005, DELTAGEN, INC., article "NIH initiative supporting placement of Deltagen, Inc. mice into public repositories"
ALTSCHUL, S. F. ET AL., J. MOL. BIOL., vol. 15, 1990, pages 403 - 410
KARLIN, S.; ALTSCHUL S. F., PROC. NATL. ACAD. SCI. USA, vol. 87, 1990, pages 2264 - 2268
KUNKEL ET AL., PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 488 - 492
F. M. AUSUBEL ET AL.: "Short Protocols in Molecular Biology", 1995, JOHN WILEY & SONS
J. SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual, 2nd ed.,", 1989, COLD SPRING HARBOR LABORATORY PRESS
J.VIROL., vol. 67, 1993, pages 5911 - 5921
HUMAN GENE THERAPY, vol. 5, 1994, pages 717 - 729
GENE THERAPY, vol. 1, 1994, pages 51 - 58
HUMAN GENE THERAPY, vol. 5, 1994, pages 793 - 801
GENE THERAPY, vol. 1, 1994, pages 165 - 169
KAKEDA ET AL., GENE THER., vol. 12, 2005, pages 852 - 856
See also references of EP 2725101A4
Attorney, Agent or Firm:
HAMADA Yuriko et al. (JP)
Yuriko Hamada (JP)
Yuriko Hamada (JP)
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