Title:
PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR, PREPARATION METHODS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2008/106860
Kind Code:
A1
Abstract:
PTP1B inhibitors with the following structure (formula I). Experiments indicate that these inhibitors can effectively inhibit the activity of protein tyrosine phosphatase 1B (PTP1B). They can be used as insulin sensitisers. They can be used to prevent, delay or treat diseases which are related to insulin antagonism mediated by PTP1B, especially diabetes type II and obesity. The invention also provides methods for preparing these inhibitors.
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Inventors:
NAN FAJUN (CN)
LI JIA (CN)
WEI YI (CN)
ZHANG WEI (CN)
LI JINGYA (CN)
SHI LEI (CN)
LI JIA (CN)
WEI YI (CN)
ZHANG WEI (CN)
LI JINGYA (CN)
SHI LEI (CN)
Application Number:
PCT/CN2008/000400
Publication Date:
September 12, 2008
Filing Date:
February 26, 2008
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA (CN)
NAN FAJUN (CN)
LI JIA (CN)
WEI YI (CN)
ZHANG WEI (CN)
LI JINGYA (CN)
SHI LEI (CN)
NAN FAJUN (CN)
LI JIA (CN)
WEI YI (CN)
ZHANG WEI (CN)
LI JINGYA (CN)
SHI LEI (CN)
International Classes:
C07D277/22; A61K31/421; A61K31/426; A61K31/427; A61K31/44; A61P3/04; A61P3/10; C07D213/55; C07D263/32; C07D417/12
Foreign References:
| EP1553091A1 | 2005-07-13 | |||
| US20040214870A1 | 2004-10-28 | |||
| JP2005112802A | 2005-04-28 | |||
| US5965558A | 1999-10-12 |
Other References:
BREYDO L. ET AL.: "Synthesis and noncovalent DNA-binding properties of thiazole derivatives related to leinamycin", TETRAHEDRON LETTERS, vol. 45, no. 29, 2004, pages 5711 - 5716, XP004516565
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FRANGIONI J.V; BEAHM P.H.; SHIFRIN V. ET AL., CELL, vol. 68, 1992, pages 544 - 560
BOUTE N.; BOUBEKEUR S.; LACASA D. ET AL., EMBO REP., vol. 4, no. 3, 2003, pages 313 - 319
HAJ F.G.; VERVEER P.J.; SQUIRE A. ET AL., SCIENCE, vol. 295, no. 5560, 2002, pages 1708 - 1711
JOHNSON T.O.; ERMOLIEFF J.; JIROUESK M.R., NAT. REV. DRUG DISC., vol. 1, no. 9, 2002, pages 696 - 709
AHMAD F.; AZEVEDO J.L.; CORTRIGHT R. ET AL., J. CLIN. INVEST., vol. 100, no. 2, 1997, pages 449 - 458
AHMAD F.; CONSIDINE R.V.; BAUER T.L. ET AL., METABOLISM, vol. 46, no. 10, 1997, pages 1140 - 1145
EGAWA K. ET AL., J. BIOL. CHEM., vol. 276, no. 13, pages 10207 - 10211
AHMAD F. ET AL., J. BIOL. CHEM., vol. 170, no. 35, 1995, pages 20503 - 20508
ELCHEBLY M. ET AL., SCIENCE, vol. 283, pages 1544 - 1548
KLAMAN L. D. ET AL., MOL. CELL. BIO., vol. 20, no. 15, pages 5479 - 5489
FORSELL P.A.; BOIE Y.; MONTALIBET T. ET AL., GENE, vol. 260, no. 1-2, 2003, pages 145 - 153
WU X.D. ET AL., J. CLIN. ENDOCRINOL METAB, vol. 86, 2001, pages 5973 - 5980
ECHWALD S.M. ET AL., DIABETES, vol. 51, 2002, pages 1 - 6
DI PAOIA R. ET AL., AM. J. HUM. GENET., vol. 70, 2002, pages 806 - 812
MALAMAS, M. S. ET AL., J. MED. CHEM., vol. 43, 2000, pages 1293 - 1310
CHRISTOPHER T. SETO ET AL., J. MED. CHEM., vol. 45, 2002, pages 3946 - 3952
See also references of EP 2133342A4
WHITE M.F.; KAHN C.R., J. BIO. CHEM., vol. 269, 1996, pages 1 - 4
FRANGIONI J.V; BEAHM P.H.; SHIFRIN V. ET AL., CELL, vol. 68, 1992, pages 544 - 560
BOUTE N.; BOUBEKEUR S.; LACASA D. ET AL., EMBO REP., vol. 4, no. 3, 2003, pages 313 - 319
HAJ F.G.; VERVEER P.J.; SQUIRE A. ET AL., SCIENCE, vol. 295, no. 5560, 2002, pages 1708 - 1711
JOHNSON T.O.; ERMOLIEFF J.; JIROUESK M.R., NAT. REV. DRUG DISC., vol. 1, no. 9, 2002, pages 696 - 709
AHMAD F.; AZEVEDO J.L.; CORTRIGHT R. ET AL., J. CLIN. INVEST., vol. 100, no. 2, 1997, pages 449 - 458
AHMAD F.; CONSIDINE R.V.; BAUER T.L. ET AL., METABOLISM, vol. 46, no. 10, 1997, pages 1140 - 1145
EGAWA K. ET AL., J. BIOL. CHEM., vol. 276, no. 13, pages 10207 - 10211
AHMAD F. ET AL., J. BIOL. CHEM., vol. 170, no. 35, 1995, pages 20503 - 20508
ELCHEBLY M. ET AL., SCIENCE, vol. 283, pages 1544 - 1548
KLAMAN L. D. ET AL., MOL. CELL. BIO., vol. 20, no. 15, pages 5479 - 5489
FORSELL P.A.; BOIE Y.; MONTALIBET T. ET AL., GENE, vol. 260, no. 1-2, 2003, pages 145 - 153
WU X.D. ET AL., J. CLIN. ENDOCRINOL METAB, vol. 86, 2001, pages 5973 - 5980
ECHWALD S.M. ET AL., DIABETES, vol. 51, 2002, pages 1 - 6
DI PAOIA R. ET AL., AM. J. HUM. GENET., vol. 70, 2002, pages 806 - 812
MALAMAS, M. S. ET AL., J. MED. CHEM., vol. 43, 2000, pages 1293 - 1310
CHRISTOPHER T. SETO ET AL., J. MED. CHEM., vol. 45, 2002, pages 3946 - 3952
See also references of EP 2133342A4
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (Block B KingSound International Certer, 116 Zizhuyuan Road, Haidian District, Beijing 7, CN)
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