Title:
PROTEOMICS-BASED RECEPTOR-LIGAND MATCHING FOR OPTIMIZING STEM CELL REPROGRAMMING
Document Type and Number:
WIPO Patent Application WO/2023/100949
Kind Code:
A1
Abstract:
The present invention is to provide a composition comprising a ligand for modulating a function of a stem cell-derived cell culture. The present invention is also to provide a method for identifying a protein in a population of proteins in a tissue and/or an organ and/or an in vitro cell culture and/or purified subcellular fraction. The present invention is further to provide a method for quantifying a target protein in a tissue and/or an organ and/or an in vitro cell culture and/or purified subcellular fraction, further comprising identifying a protein, the expression level of which is larger or lower in the iPSC- or ESC-derived cell culture than in the iPSC or ESC culture, and identifying a ligand or transcription factor against the protein, the expression level of which is larger or lower in the iPSC- or ESC-derived cell culture than in the iPSC or ESC culture.
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Inventors:
TAOUFIQ ZACHARIE (JP)
DIMITROV DIMITAR (JP)
KHANDARKHAEVA MARINA (JP)
TAKAHASHI TOMOYUKI (JP)
VILLAR-BRIONES ALEJANDRO (JP)
MICHEAL C ROY (JP)
DIMITROV DIMITAR (JP)
KHANDARKHAEVA MARINA (JP)
TAKAHASHI TOMOYUKI (JP)
VILLAR-BRIONES ALEJANDRO (JP)
MICHEAL C ROY (JP)
Application Number:
PCT/JP2022/044253
Publication Date:
June 08, 2023
Filing Date:
November 30, 2022
Export Citation:
Assignee:
OKINAWA INST SCIENCE & TECH SCHOOL CORP (JP)
International Classes:
C12N5/10; C12N5/079; C12Q1/00
Domestic Patent References:
| WO2017009766A1 | 2017-01-19 | |||
| WO2021016607A1 | 2021-01-28 |
Other References:
ČERVENKA JAKUB, TYLEČKOVÁ JIŘINA, KUPCOVÁ SKALNÍKOVÁ HELENA, VODIČKOVÁ KEPKOVÁ KATEŘINA, POLIAKH IEVGENIIA, VALEKOVÁ IVONA, PFEIFE: "Proteomic Characterization of Human Neural Stem Cells and Their Secretome During in vitro Differentiation", FRONTIERS IN CELLULAR NEUROSCIENCE, vol. 14, XP093069990, DOI: 10.3389/fncel.2020.612560
UMEMORI HISASHI, LINHOFF MICHAEL W, ORNITZ DAVID M, SANES JOSHUA R: "FGF22 and Its Close Relatives Are Presynaptic Organizing Molecules in the Mammalian Brain", CELL, ELSEVIER, AMSTERDAM NL, vol. 118, no. 2, 1 July 2004 (2004-07-01), Amsterdam NL , pages 257 - 270, XP093069999, ISSN: 0092-8674, DOI: 10.1016/j.cell.2004.06.025
TAOUFIQ ZACHARIE, NINOV MOMCHIL, VILLAR-BRIONES ALEJANDRO, WANG HAN-YING, SASAKI TOSHIO, ROY MICHAEL C., BEAUCHAIN FRANCOIS, MORI : "Hidden proteome of synaptic vesicles in the mammalian brain", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 117, no. 52, 29 December 2020 (2020-12-29), pages 33586 - 33596, XP093070002, ISSN: 0027-8424, DOI: 10.1073/pnas.2011870117
LI QIAN, FENG YI, XUE YINGCHAO, ZHAN XIPING, FU YI, GUI GEGE, ZHOU WEIQIANG, RICHARD JEAN-PHILIPPE, TAGA ARENS, LI PAN, MAO XIAOBO: "Edaravone activates the GDNF/RET neurotrophic signaling pathway and protects mRNA-induced motor neurons from iPS cells", MOLECULAR NEURODEGENERATION, vol. 17, no. 1, 1 December 2022 (2022-12-01), XP093070005, DOI: 10.1186/s13024-021-00510-y
UMEMORI HISASHI, LINHOFF MICHAEL W, ORNITZ DAVID M, SANES JOSHUA R: "FGF22 and Its Close Relatives Are Presynaptic Organizing Molecules in the Mammalian Brain", CELL, ELSEVIER, AMSTERDAM NL, vol. 118, no. 2, 1 July 2004 (2004-07-01), Amsterdam NL , pages 257 - 270, XP093069999, ISSN: 0092-8674, DOI: 10.1016/j.cell.2004.06.025
TAOUFIQ ZACHARIE, NINOV MOMCHIL, VILLAR-BRIONES ALEJANDRO, WANG HAN-YING, SASAKI TOSHIO, ROY MICHAEL C., BEAUCHAIN FRANCOIS, MORI : "Hidden proteome of synaptic vesicles in the mammalian brain", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 117, no. 52, 29 December 2020 (2020-12-29), pages 33586 - 33596, XP093070002, ISSN: 0027-8424, DOI: 10.1073/pnas.2011870117
LI QIAN, FENG YI, XUE YINGCHAO, ZHAN XIPING, FU YI, GUI GEGE, ZHOU WEIQIANG, RICHARD JEAN-PHILIPPE, TAGA ARENS, LI PAN, MAO XIAOBO: "Edaravone activates the GDNF/RET neurotrophic signaling pathway and protects mRNA-induced motor neurons from iPS cells", MOLECULAR NEURODEGENERATION, vol. 17, no. 1, 1 December 2022 (2022-12-01), XP093070005, DOI: 10.1186/s13024-021-00510-y
Attorney, Agent or Firm:
KUZUWA, Kiyoshi (JP)
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