Title:
PYRIDINE AND BENZENE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2019/107533
Kind Code:
A1
Abstract:
The present invention provides a compound for suppressing cell transformation, the compound being represented by the following general formula (wherein n is 1 or 2; R1 is H, methoxy(-OCH3), or Cl; R2 is H, -OCH3, or Cl; R3 is H, -OCH3, Cl, or F; R4 is H or OH; R5 is H, hydroxyl (-OH), Br, 3-methyl-2-butyl, or phenyl; and R6 is H or -OH), or a salt thereof.
Inventors:
OTSUKA MASAMI (JP)
NIWA SHIN-ICHIRO (JP)
OGURA DAI (JP)
IDE KAYOKO (JP)
NIWA SHIN-ICHIRO (JP)
OGURA DAI (JP)
IDE KAYOKO (JP)
Application Number:
PCT/JP2018/044133
Publication Date:
June 06, 2019
Filing Date:
November 30, 2018
Export Citation:
Assignee:
SCIENCE FARM LTD (JP)
LINK GENOMICS INC (JP)
LINK GENOMICS INC (JP)
International Classes:
C07C215/50; A61K31/44; A61K31/4465; A61K31/454; A61P29/00; A61P35/00; A61P43/00; C07C217/08; C07C229/38; C07C323/25; C07C327/48; C07D211/14; C07D211/22; C07D211/34; C07D213/78
Domestic Patent References:
| WO2018005336A1 | 2018-01-04 |
Foreign References:
| JPS5245773B2 | 1977-11-18 | |||
| US3947389A | 1976-03-30 | |||
| GB786215A | 1957-11-13 | |||
| JPS4750372B1 | ||||
| JP2007230909A | 2007-09-13 |
Other References:
REHSE, KLAUS ET AL.: "Platelet aggregation-inhibiting and anticoagulant effects of oligoamines. III. 1,3-Phenylenebis(alkanamines", ARCHIV DER PHARMAZIE, vol. 320, no. 3, 1 March 1987 (1987-03-01), pages 228 - 233, XP009015645, DOI: 10.1002/ardp.19873200308
GASIOREK, MARTIN ET AL.: "Unwinding DNA and RNA with Synthetic Complexes: On the Way to Artificial Helicases", CHEMISTRY - A EUROPEAN JOURNAL, vol. 21, no. 50, 2015 - 27 October 2015 (2015-10-27), pages 18328 - 18332, XP055616357
HOSONO, TETSUJI ET AL.: "Antiviral activities against herpes simplex virus type 1 by HPH derivatives and their structure-activity relationships", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 1, 2008, pages 371 - 374, XP022410917, DOI: 10.1016/j.bmcl.2007.10.065
GASIOREK, MARTIN ET AL.: "Unwinding DNA and RNA with Synthetic Complexes: On the Way to Artificial Helicases", CHEMISTRY - A EUROPEAN JOURNAL, vol. 21, no. 50, 2015 - 27 October 2015 (2015-10-27), pages 18328 - 18332, XP055616357
HOSONO, TETSUJI ET AL.: "Antiviral activities against herpes simplex virus type 1 by HPH derivatives and their structure-activity relationships", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 1, 2008, pages 371 - 374, XP022410917, DOI: 10.1016/j.bmcl.2007.10.065
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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