PYRIDINE DERIVATIVE AND USE THEREOF IN MEDICINE - CHENGDU BAIYU PHARMACEUTICAL CO LTD

Title:

PYRIDINE DERIVATIVE AND USE THEREOF IN MEDICINE

Document Type and Number:

WIPO Patent Application WO/2022/127774

Kind Code:

A1

Abstract:

Disclosed are a pyridine derivative and the use thereof in medicine. The pyridine derivative has a good binding effect with LANCL2 protein, and has a significant efficacy on ulcerative colitis.

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Inventors:

ZHANG JING (CN)
ZHOU XIBING (CN)
WEI YONGGANG (CN)
SUN YI (CN)

Application Number:

PCT/CN2021/137836

Publication Date:

June 23, 2022

Filing Date:

December 14, 2021

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Assignee:

CHENGDU BAIYU PHARMACEUTICAL CO LTD (CN)

International Classes:

C07D401/14; A61K31/4184; A61K31/4427; A61K31/497; A61P29/00; C07D487/04; C07D487/10

Domestic Patent References:

WO2016064445A1	2016-04-28
WO2021127472A1	2021-06-24

Foreign References:

CN111511904A	2020-08-07
US20110275558A1	2011-11-10

Other References:

ADRIA CARBO, RICHARD D. GANDOUR, RAQUEL HONTECILLAS, NOAH PHILIPSON, AYKUT UREN, JOSEP BASSAGANYA-RIERA: "An N , N -Bis(benzimidazolylpicolinoyl)piperazine (BT-11): A Novel Lanthionine Synthetase C-Like 2-Based Therapeutic for Inflammatory Bowel Disease", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 59, no. 22, 23 November 2016 (2016-11-23), US , pages 10113 - 10126, XP055553688, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.6b00412

Attorney, Agent or Firm:

SINO-CREATIVITY INTELLECTUAL PROPERTY LAW FIRM (CN)

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