Title:
PYRIMIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2011/078143
Kind Code:
A1
Abstract:
Disclosed is a novel compound which has histamine H4 receptor modulating activity. Specifically disclosed is a compound represented by formula (I), a pharmaceutically acceptable salt thereof, or a solvate of the compound or salt. (In the formula, ring A represents an aromatic heterocyclic ring; -B1 represents a group represented by -X-(CR8aR8b)m-Y; X represents a group represented by N(R7c) or the like; R7c represents a hydrogen atom, a substituted or unsubstituted alkyl group or the like; R8a and R8b each independently represents a hydrogen atom, a halogen atom or the like; m represents an integer of 0-5; Y represents a substituted or unsubstituted cycloalkylthio group or the like; and -B2 represents a group represented by formula (II) (wherein R10s each independently represents a substituted or unsubstituted alkyl group or the like; R11 represents a hydrogen atom, a substituted or unsubstituted alkyl group or the like; and p represents an integer of 0-4) or the like.)
Inventors:
MASUDA TSUTOMU (JP)
TACHIBANA YUKI (JP)
MIYAGAWA MASAYOSHI (JP)
HASEGAWA TSUYOSHI (JP)
TOBINAGA HIROYUKI (JP)
TACHIBANA YUKI (JP)
MIYAGAWA MASAYOSHI (JP)
HASEGAWA TSUYOSHI (JP)
TOBINAGA HIROYUKI (JP)
Application Number:
PCT/JP2010/072951
Publication Date:
June 30, 2011
Filing Date:
December 21, 2010
Export Citation:
Assignee:
SHIONOGI & CO (JP)
MASUDA TSUTOMU (JP)
TACHIBANA YUKI (JP)
MIYAGAWA MASAYOSHI (JP)
HASEGAWA TSUYOSHI (JP)
TOBINAGA HIROYUKI (JP)
MASUDA TSUTOMU (JP)
TACHIBANA YUKI (JP)
MIYAGAWA MASAYOSHI (JP)
HASEGAWA TSUYOSHI (JP)
TOBINAGA HIROYUKI (JP)
International Classes:
C07D239/48; A61K31/506; A61K31/517; A61K31/519; A61K31/5377; A61P1/00; A61P9/10; A61P11/00; A61P11/02; A61P17/00; A61P17/06; A61P25/04; A61P27/02; A61P29/00; A61P37/08; A61P43/00; C07D239/95; C07D401/04; C07D401/12; C07D403/04; C07D403/12; C07D405/04; C07D405/12; C07D405/14; C07D413/12; C07D417/04; C07D417/12; C07D471/04; C07D473/32; C07D487/04; C07D491/052; C07D491/113; C07D495/04; C07D498/04
Domestic Patent References:
| WO2007113202A1 | 2007-10-11 | |||
| WO2002053557A1 | 2002-07-11 | |||
| WO2009078999A1 | 2009-06-25 | |||
| WO2009079000A1 | 2009-06-25 | |||
| WO2009023978A1 | 2009-02-26 | |||
| WO2009152325A1 | 2009-12-17 | |||
| WO2008122378A1 | 2008-10-16 | |||
| WO2010046109A1 | 2010-04-29 |
Foreign References:
| DE2121950A1 | 1972-11-23 | |||
| EP0852226A1 | 1998-07-08 | |||
| JPH0959160A | 1997-03-04 | |||
| EP0658548A1 | 1995-06-21 | |||
| GB1185039A | 1970-03-18 |
Other References:
MORIMOTO, H. ET AL.: "Modifications and structure- activity relationships at the 2-position of 4-sulfonamidopyrimidine derivatives as potent endothelin antagonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 12, no. 1, 2001, pages 81 - 84, XP002599929, DOI: doi:10.1016/S0960-894X(01)00682-5
Attorney, Agent or Firm:
TAKAYAMA, Hirotsugu et al. (JP)
Hiromitsu Takayama (JP)
Hiromitsu Takayama (JP)
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