PYRROLIDONES WITH ANTI-HIV ACTIVITY

Title:

PYRROLIDONES WITH ANTI-HIV ACTIVITY

Document Type and Number:

WIPO Patent Application WO2004037784

Kind Code:

A3

Abstract:

The present invention relates to inhibition of viruses, e.g., HIV using pyrrolidones and compounds related to pyrrolidones. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions that inhibit HIV in a cell; as well as to methods of prophylaxis, and therapy related to HIV infection and related disease states such as AIDS.

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Inventors:

WU BAOGEN (US)
HE YUN (US)
NGYUEN TRUC (US)
KUHEN KELLI L (US)
ELLIS DAVID ARCHER (US)
JIANG TAO (US)

Application Number:

PCT/US2003/033560

Publication Date:

August 19, 2004

Filing Date:

October 21, 2003

Export Citation:

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Assignee:

IRM LLC (US)
WU BAOGEN (US)
HE YUN (US)
NGYUEN TRUC (US)
KUHEN KELLI L (US)
ELLIS DAVID ARCHER (US)
JIANG TAO (US)

International Classes:

C07D207/26; C07D401/04; C07D401/12; C07D403/04; C07D403/12; C07D405/14; C07D413/12; C07D417/12; (IPC1-7): C07D401/04; A61K31/4015; A61K31/4439; A61K31/497; A61K31/506; C07D207/26; C07D403/04

Other References:

BACHER E. ET AL: "N-arylrolipam derivatives as potent and selective PDE4 inhibitors", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 8, no. 22, 1998, pages 3229 - 3234, XP004143732
AEBISCHER E. ET AL: "Synthesis of N-arylrolipram derivatives - potent and selective phosphodiesterase-IV inhibitors - by copper catalyzed lactam-aryl halide coupling", HETEROCYCLES, vol. 48, no. 11, 1998, pages 2225 - 2229, XP002978144

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