Title:
PYRROLOCARBAZOLE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1998/009967
Kind Code:
A1
Abstract:
Pyrrolocarbazole derivatives represented by general formula (I) or pharmacologically acceptable salts thereof, wherein the ring (C) represents a benzene or cyclohexene ring; X and Y are the same or different and each represents carbonyl or methylene; R?1� represents lower alkyl or aralkyl; R?2� represents hydrogen, optionally substituted lower alkyl, lower alkenyl, or optionally substituted aralkyl; and R?3�, R?4�, R?5�, R?6�, R?7�, R?8�, R?9�, R?10� and R?11� are the same or different and each represents hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, halogeno, nitro, optionally substituted lower alkanoyl, NR?12�R?13�, OR?14�, NHCONHR?16�, or COR?17�. These compounds have the effect of promoting thrombopoiesis, which makes them useful in the treatment of thrombopenia.
Inventors:
INO YOJI (JP)
KANAI FUMIHIKO (JP)
MURAKAMI SATORU (JP)
MURAKATA CHIKARA (JP)
AKAMA TSUTOMU (JP)
SHIOTSU YUKIMASA (JP)
YAMASHITA KINYA (JP)
AKINAGA SHIRO (JP)
TAMAOKI TATSUYA (JP)
KANAI FUMIHIKO (JP)
MURAKAMI SATORU (JP)
MURAKATA CHIKARA (JP)
AKAMA TSUTOMU (JP)
SHIOTSU YUKIMASA (JP)
YAMASHITA KINYA (JP)
AKINAGA SHIRO (JP)
TAMAOKI TATSUYA (JP)
Application Number:
PCT/JP1997/003153
Publication Date:
March 12, 1998
Filing Date:
September 08, 1997
Export Citation:
Assignee:
KYOWA HAKKO KOGYO KK (JP)
INO YOJI (JP)
KANAI FUMIHIKO (JP)
MURAKAMI SATORU (JP)
MURAKATA CHIKARA (JP)
AKAMA TSUTOMU (JP)
SHIOTSU YUKIMASA (JP)
YAMASHITA KINYA (JP)
AKINAGA SHIRO (JP)
TAMAOKI TATSUYA (JP)
INO YOJI (JP)
KANAI FUMIHIKO (JP)
MURAKAMI SATORU (JP)
MURAKATA CHIKARA (JP)
AKAMA TSUTOMU (JP)
SHIOTSU YUKIMASA (JP)
YAMASHITA KINYA (JP)
AKINAGA SHIRO (JP)
TAMAOKI TATSUYA (JP)
International Classes:
C07D487/04; (IPC1-7): C07D487/04; A61K31/40
Domestic Patent References:
| WO1996028447A1 | 1996-09-19 |
Foreign References:
| JPH07304771A | 1995-11-21 | |||
| JPH02142791A | 1990-05-31 |
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