Title:
PYRROLOPYRIDAZINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/1995/019980
Kind Code:
A1
Abstract:
A pyrrolopyridazine derivative represented by general formula (I) and a pharmacologically acceptable salt thereof, wherein R1 represents C2-C6 alkenyl, halogenated C2-C6 alkenyl, (C6-C10 aryl)-substituted C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, (C3-C7 cycloalkyl)-substituted C1-C6 alkyl, (C5-C7 cycloalkenyl)-substituted C1-C6 alkyl or halogenated C1-C6 alkyl; R2 and R3 represent each independently hydrogen, C1-C6 alkyl or C6-C10 aryl; R4 represents hydrogen or C1-C6 alkyl; R5 represents C6-C10 aryl or five- to ten-membered heteroaryl wherein heteroatom(s) is(are) selected from among nitrogen, oxygen and sulfur atoms; A represents C1-C3 alkylene; X represents imino, oxygen, sulfur or methylene; m represents 0 or 1; and n represents 0 or 1. The derivative has excellent effects of suppressing gastric secretion and protecting gastric mucosa and an excellent antibacterial activity against Helicobacter pylori, thus being useful as a preventive or remedy for ulcerative diseases and the like.
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Inventors:
KIMURA TOMIO (JP)
FUJIHARA YOSHIMI (JP)
SHIBAKAWA NOBUHIKO (JP)
FUJIWARA HIROSHI (JP)
ITOH ETSURO (JP)
MATSUNOBU KEIJI (JP)
TABATA KEIICHI (JP)
YASUDA HIROSHI (JP)
FUJIHARA YOSHIMI (JP)
SHIBAKAWA NOBUHIKO (JP)
FUJIWARA HIROSHI (JP)
ITOH ETSURO (JP)
MATSUNOBU KEIJI (JP)
TABATA KEIICHI (JP)
YASUDA HIROSHI (JP)
Application Number:
PCT/JP1995/000038
Publication Date:
July 27, 1995
Filing Date:
January 18, 1995
Export Citation:
Assignee:
SANKYO CO (JP)
UBE INDUSTRIES (JP)
KIMURA TOMIO (JP)
FUJIHARA YOSHIMI (JP)
SHIBAKAWA NOBUHIKO (JP)
FUJIWARA HIROSHI (JP)
ITOH ETSURO (JP)
MATSUNOBU KEIJI (JP)
TABATA KEIICHI (JP)
YASUDA HIROSHI (JP)
UBE INDUSTRIES (JP)
KIMURA TOMIO (JP)
FUJIHARA YOSHIMI (JP)
SHIBAKAWA NOBUHIKO (JP)
FUJIWARA HIROSHI (JP)
ITOH ETSURO (JP)
MATSUNOBU KEIJI (JP)
TABATA KEIICHI (JP)
YASUDA HIROSHI (JP)
International Classes:
A61K31/5025; A61P1/04; E04F13/08; C07D487/04; E04F13/073; E04F13/26; E04F19/02; (IPC1-7): C07D487/04; A61K31/50
Domestic Patent References:
| WO1991017164A1 | 1991-11-14 |
Other References:
See also references of EP 0742218A4
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