Title:
QUINAZOLINE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/005137
Kind Code:
A1
Abstract:
Disclosed are a quinazoline compound, intermediate, preparation method, pharmaceutical composition and use thereof. The quinazoline compound of the present invention has a good inhibitory effect on the protein kinase JAK, and can be used for the preparation of a medicine for the prevention, treatment or adjuvant treatment of a variety of diseases associated with the expression or activity of JAK, in particular tumour diseases and immune diseases.
Inventors:
BAI XU (CN)
YU JIANXIN (CN)
WANG WANHE (CN)
ZHANG YONG (CN)
ZHENG LIANYOU (CN)
XIA GUANGXIN (CN)
ZHANG CHUNLING (CN)
WANG YUJI (CN)
ZHOU QIAN (CN)
ZHANG DAPENG (CN)
YU JIANXIN (CN)
WANG WANHE (CN)
ZHANG YONG (CN)
ZHENG LIANYOU (CN)
XIA GUANGXIN (CN)
ZHANG CHUNLING (CN)
WANG YUJI (CN)
ZHOU QIAN (CN)
ZHANG DAPENG (CN)
Application Number:
PCT/CN2016/088089
Publication Date:
January 12, 2017
Filing Date:
July 01, 2016
Export Citation:
Assignee:
UNIV JILIN (CN)
SHANGHAI PHARMACEUTICALS HOLDING CO LTD (CN)
SHANGHAI PHARMACEUTICALS HOLDING CO LTD (CN)
International Classes:
C07D239/84; A61K31/5377; A61P19/02; A61P29/00
Domestic Patent References:
| WO2016133935A1 | 2016-08-25 | |||
| WO2015027222A2 | 2015-02-26 |
Foreign References:
| CN101454294A | 2009-06-10 |
Other References:
BURSAVICH, M.G. ET AL.: "Novel Mps1 Kinase Inhibitors: from Purine to Pyrrolopyrimidine and Quinazoline Leads", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, no. 24, 11 October 2013 (2013-10-11), pages 6 832, XP028788008, ISSN: 0960-894X
HE, Y.J. ET AL.: "Synthesis and SAR of Novel Penetrant c-jun N-terminal Kinase (JNK) Inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, no. 6, 22 January 2011 (2011-01-22), pages 1722, XP028169562, ISSN: 0960-894X
HE, Y.J. ET AL.: "Synthesis and SAR of Novel Penetrant c-jun N-terminal Kinase (JNK) Inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, no. 6, 22 January 2011 (2011-01-22), pages 1722, XP028169562, ISSN: 0960-894X
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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