Title:
QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS
Document Type and Number:
WIPO Patent Application WO2007014941
Kind Code:
A8
Abstract:
Use of a compound for the manufacture of a medicament for the treatment of a bacterial infection provided that the bacterial infection is other than a Mycobacterial infection, said compound being a compound of formula (I), a pharmaceutically acceptable acid or base addition salt, a quaternary amine, a stereochemically isomeric form, a tautomeric form or a N-oxide form thereof, wherein R1 is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; p is 1 to 3; s is O to 4; R2 is hydrogen; halo; alkyl; hydroxy; mercapto; optionally substituted alkyloxy; alkyloxyalkyloxy; alkylthio; mono or di(alkyl)amino wherein alkyl may optionally be substituted; Ar; Het or a radical of formula (II), R3 is alkyl, Ar, Ar-alkyl, Het or Het-alkyl; q is O to 4 ; R4 and R5 each independently are hydrogen, alkyl or benzyl; or R4 and R5 may be taken together including the N to which they are attached ; R6 is hydrogen, halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl ; or two vicinal R6 radicals may be taken together to form together with the phenyl ring to which they are attached a naphthyl; r is 1 to 5 ; R7 is hydrogen, alkyl, Ar or Het ; R8 is hydrogen, alkyl, hydroxyl, aminocarbonyl, mono-or di(alkyl)aminocarbonyl, Ar, Het, alkyl substituted with one or two Het, alkyl substituted with one or two Ar, Het-C(=O)- or Ar-C(=O)-; provided that when the R3 bearing radical is placed in position 3 of the quinoline moiety; R7 is placed in position 4 and R2 is placed in position 2 and represents hydrogen, hydroxy, mercapto, alkyloxy, alkyloxyalkyloxy, alkylthio, mono or di(alkyl)amino or a radical of formula (III), then s is 1 to 4.
Inventors:
GUILLEMONT JEROME EMILE GEORGE (FR)
PASQUIER ELISABETH THERESE JEA (FR)
LANCOIS DAVID FRANCIS ALAIN (FR)
ANDRIES KOENRAAD JOZEF LODEWIJ (BE)
KOUL ANIL (BE)
BACKX LEO JACOBUS JOZEF (BE)
MEERPOEL LIEVEN (BE)
PASQUIER ELISABETH THERESE JEA (FR)
LANCOIS DAVID FRANCIS ALAIN (FR)
ANDRIES KOENRAAD JOZEF LODEWIJ (BE)
KOUL ANIL (BE)
BACKX LEO JACOBUS JOZEF (BE)
MEERPOEL LIEVEN (BE)
Application Number:
PCT/EP2006/064858
Publication Date:
May 03, 2007
Filing Date:
July 31, 2006
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NV (BE)
GUILLEMONT JEROME EMILE GEORGE (FR)
PASQUIER ELISABETH THERESE JEA (FR)
LANCOIS DAVID FRANCIS ALAIN (FR)
ANDRIES KOENRAAD JOZEF LODEWIJ (BE)
KOUL ANIL (BE)
BACKX LEO JACOBUS JOZEF (BE)
MEERPOEL LIEVEN (BE)
GUILLEMONT JEROME EMILE GEORGE (FR)
PASQUIER ELISABETH THERESE JEA (FR)
LANCOIS DAVID FRANCIS ALAIN (FR)
ANDRIES KOENRAAD JOZEF LODEWIJ (BE)
KOUL ANIL (BE)
BACKX LEO JACOBUS JOZEF (BE)
MEERPOEL LIEVEN (BE)
International Classes:
A61K31/47; A61P31/04; C07D215/18; C07D215/22
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