Title:
QUINOLINE DERIVATIVES AS ANTIBACTERICAL AGENTS
Document Type and Number:
WIPO Patent Application WO2007014940
Kind Code:
A8
Abstract:
Use of a compound for the manufacture of a medicament for the treatment of a bacterial infection provided that the bacterial infection is other than a Mycobacterial infection, said compound being a compound of Formula (Ia) or (Ib), a pharmaceutically acceptable acid or base addition salt thereof, a quaternary amine thereof, a stereochemically isomeric form thereof, a tautomeric form thereof or a N-oxide form thereof, wherein R1 is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; p is 1, 2 or 3; R2 is hydrogen; alkyl; hydroxy; mercapto; optionally substituted alkyloxy; alkyloxyalkyloxy; alkylthio; mono or di(alkyl)amino wherein alkyl may optionally be substituted; Ar; Het or a radical of Formula (??); R3 is alkyl, Ar, Ar-alkyl, Het or Het-alkyl; q is zero, 1, 2, 3 or 4; X is a direct bond or CH2; R4 and R5 each independently are hydrogen, alkyl or benzyl; or R4 and R5 may be taken together including the N to which they are attached; R6 is hydrogen or a radical of Formula (III); R7 is hydrogen, alkyl, Ar or Het; R8 is hydrogen or alkyl; R9 is oxo ; or R8 and R9 together form the radical -CH=CH-N=.
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Inventors:
ANDRIES KOENRAAD JOZEF LODEWIJ (BE)
KOUL ANIL (BE)
GUILLEMONT JEROME EMILE GEORGE (FR)
PASQUIER ELISABETH THERESE JEA (FR)
LANCOIS DAVID FRANCIS ALAIN (FR)
KOUL ANIL (BE)
GUILLEMONT JEROME EMILE GEORGE (FR)
PASQUIER ELISABETH THERESE JEA (FR)
LANCOIS DAVID FRANCIS ALAIN (FR)
Application Number:
PCT/EP2006/064856
Publication Date:
May 18, 2007
Filing Date:
July 31, 2006
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NV (BE)
ANDRIES KOENRAAD JOZEF LODEWIJ (BE)
KOUL ANIL (BE)
GUILLEMONT JEROME EMILE GEORGE (FR)
PASQUIER ELISABETH THERESE JEA (FR)
LANCOIS DAVID FRANCIS ALAIN (FR)
ANDRIES KOENRAAD JOZEF LODEWIJ (BE)
KOUL ANIL (BE)
GUILLEMONT JEROME EMILE GEORGE (FR)
PASQUIER ELISABETH THERESE JEA (FR)
LANCOIS DAVID FRANCIS ALAIN (FR)
International Classes:
A61K31/47; A61P31/04; C07D215/22
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