Title:
R-FORM OF 4-(2,4-DIFLUOROPHENYL)-2-(1H-INDOL-3-YL)-4-OXO-BUTANOIC ACID
Document Type and Number:
WIPO Patent Application WO/2023/013756
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a low molecular weight compound that has an action of increasing the NAD+ amount in animal cells and that has a low cellular toxicity against animal cells. The present invention uses a compound represented by formula (A-1) or a physiologically acceptable salt thereof.
Inventors:
ABE TAKAAKI (JP)
MATSUMOTO YOTARO (JP)
SUZUKI TAKEHIRO (JP)
KUJIRAI RYOTA (JP)
MATSUMOTO YOTARO (JP)
SUZUKI TAKEHIRO (JP)
KUJIRAI RYOTA (JP)
Application Number:
PCT/JP2022/030040
Publication Date:
February 09, 2023
Filing Date:
August 05, 2022
Export Citation:
Assignee:
UNIV TOHOKU (JP)
International Classes:
C07D209/18; A23L33/10; A61K31/405; A61P3/00; A61P43/00
Foreign References:
| JP2017105729A | 2017-06-15 | |||
| JP2018127429A | 2018-08-16 | |||
| JP2019116453A | 2019-07-18 |
Other References:
ABE, TAKAAKI: "World's first all-Japan clinical trial of MA-5, a drug for treating mitochondrial diseases originating in Japan", FISCAL 2017 RESULTS REPORT OF THE WORLD'S FIRST ALL-JAPAN CLINICAL TRIAL OF MA-5, A DRUG FOR MITOCHONDRIAL DISEASES ORIGINATING IN JAPAN, AMED RESEARCH AND DEVELOPMENT PROJECT DATABASE, JP, JP, pages 1 - 5, XP009543590, Retrieved from the Internet [retrieved on 20220826]
NOKIA, NOKIA SHANGHAI BELL: "(TP to TS 38.423, LTE_NR_DC_enh2-Core) Adding first procedures for the CPAC", 3GPP DRAFT; R3-211567, 3RD GENERATION PARTNERSHIP PROJECT (3GPP), MOBILE COMPETENCE CENTRE ; 650, ROUTE DES LUCIOLES ; F-06921 SOPHIA-ANTIPOLIS CEDEX ; FRANCE, vol. RAN WG3, no. E-meeting; 20210517 - 20210528, 6 May 2021 (2021-05-06), Mobile Competence Centre ; 650, route des Lucioles ; F-06921 Sophia-Antipolis Cedex ; France , XP052001359
SUZUKI, TAKEHIRO; ABE, TAKAAKI: "New therapeutics for mitochondrial diseases by mitochondria-targeted drug MA-5", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, BIOMEDICAL DRUGS PUBLICATION, JP, vol. 260, no. 1, 7 January 2017 (2017-01-07), JP , pages 98 - 104, XP009543395, ISSN: 0039-2359
SUZUKI, TAKEHIRO; ABE, TAKAAKI: "Development of New Therapeutics for Mitochondrial Disease: Bridging between Basic Researches and Clinical Implications of Mitochondrial Medicine", KAGAKU TO SEIBUTSU - CHEMISTRY AND BIOLOGY, GAKKAI SHUPPAN SENTA / JAPAN SCIENTIFIC SOCIETIES PRESS, JP, vol. 59, no. 7, 1 July 2021 (2021-07-01), JP , pages 339 - 345, XP009543393, ISSN: 0453-073X, DOI: 10.1271/kagakutoseibutsu.59.339
"Mitochondria and disease (genetic medicine mook; 35)", 10 May 2020, MEDICAL DO, JP, ISBN: 978-4-909508-06-5, article SUZUKI, TAKEHIRO, ABE, TAKAAKI: "2.Treatment of mitochondrial disorders with mitochondrial function improving agent MA-5", pages: 210 - 217, XP009543271
NOKIA, NOKIA SHANGHAI BELL: "(TP to TS 38.423, LTE_NR_DC_enh2-Core) Adding first procedures for the CPAC", 3GPP DRAFT; R3-211567, 3RD GENERATION PARTNERSHIP PROJECT (3GPP), MOBILE COMPETENCE CENTRE ; 650, ROUTE DES LUCIOLES ; F-06921 SOPHIA-ANTIPOLIS CEDEX ; FRANCE, vol. RAN WG3, no. E-meeting; 20210517 - 20210528, 6 May 2021 (2021-05-06), Mobile Competence Centre ; 650, route des Lucioles ; F-06921 Sophia-Antipolis Cedex ; France , XP052001359
SUZUKI, TAKEHIRO; ABE, TAKAAKI: "New therapeutics for mitochondrial diseases by mitochondria-targeted drug MA-5", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, BIOMEDICAL DRUGS PUBLICATION, JP, vol. 260, no. 1, 7 January 2017 (2017-01-07), JP , pages 98 - 104, XP009543395, ISSN: 0039-2359
SUZUKI, TAKEHIRO; ABE, TAKAAKI: "Development of New Therapeutics for Mitochondrial Disease: Bridging between Basic Researches and Clinical Implications of Mitochondrial Medicine", KAGAKU TO SEIBUTSU - CHEMISTRY AND BIOLOGY, GAKKAI SHUPPAN SENTA / JAPAN SCIENTIFIC SOCIETIES PRESS, JP, vol. 59, no. 7, 1 July 2021 (2021-07-01), JP , pages 339 - 345, XP009543393, ISSN: 0453-073X, DOI: 10.1271/kagakutoseibutsu.59.339
"Mitochondria and disease (genetic medicine mook; 35)", 10 May 2020, MEDICAL DO, JP, ISBN: 978-4-909508-06-5, article SUZUKI, TAKEHIRO, ABE, TAKAAKI: "2.Treatment of mitochondrial disorders with mitochondrial function improving agent MA-5", pages: 210 - 217, XP009543271
Attorney, Agent or Firm:
OHNO Seiji et al. (JP)
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