RADIOLABELED ACTIVATED ESTER AND PRECURSOR THEREOF

Title:

RADIOLABELED ACTIVATED ESTER AND PRECURSOR THEREOF

Document Type and Number:

WIPO Patent Application WO/2024/019014

Kind Code:

A1

Abstract:

Provided as a precursor of a radioactive halogen-labeled compound is a compound represented by general formula (I) [in the formula, R1 represents a leaving group that can undergo nucleophilic substitution by a halide ion, R2 represents a leaving group in which nucleophilic substitution proceeds by an amino group, and R3 represents a hydrogen atom or a halogen atom.].

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Inventors:

TANAKA HIROSHI (JP)
UEHARA TOMOYA (JP)

Application Number:

PCT/JP2023/026069

Publication Date:

January 25, 2024

Filing Date:

July 14, 2023

Export Citation:

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Assignee:

TOKYO INST TECH (JP)
UNIV CHIBA NAT UNIV CORP (JP)
TAIYO NIPPON SANSO CORP (JP)

International Classes:

C07D249/04; A61K51/00; C07D405/06

Domestic Patent References:

WO2019151384A1	2019-08-08
WO2013042668A1	2013-03-28

Other References:

SUZUKI HIROYUKI, KAIZUKA YUTA, TATSUTA MAHO, TANAKA HIROSHI, WASHIYA NANA, SHIRAKAMI YOSHIFUMI, OOE KAZUHIRO, TOYOSHIMA ATSUSHI, W: "Neopentyl Glycol as a Scaffold to Provide Radiohalogenated Theranostic Pairs of High In Vivo Stability", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 64, no. 21, 11 November 2021 (2021-11-11), US , pages 15846 - 15857, XP093131176, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.1c01147

Attorney, Agent or Firm:

NOMURA, Kenichi et al. (JP)

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