Title:
RAGE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2016/158810
Kind Code:
A1
Abstract:
This agent for the prevention and/or treatment of conditions associated with RAGE/ligand interactions, containing as an active ingredient a compound represented by formula (I): (in the formula, each of the symbols is defined as in the description) or a pharmacologically permissible salt thereof (where R2 is not a hydrogen atom when X is an alkylene group substituted by a hydroxy group), has an exceptional RAGE inhibitory effect and is useful in the prevention and/or treatment of various conditions associated with: acute inflammation, such as septicemia, ischemia reperfusion injury, and acute pneumonia; and chronic inflammation, such as rheumatoid arthritis, diabetes, Alzheimer's disease, amyotrophic lateral sclerosis, atherosclerosis, autoimmune disease, multiple sclerosis, and cancer.
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Inventors:
TANUMA SEI-ICHI (JP)
YOSHIMORI ATSUSHI (JP)
INOUE SHIGEAKI (JP)
ABE TAKEHIKO (JP)
YOSHIMORI ATSUSHI (JP)
INOUE SHIGEAKI (JP)
ABE TAKEHIKO (JP)
Application Number:
PCT/JP2016/059780
Publication Date:
October 06, 2016
Filing Date:
March 26, 2016
Export Citation:
Assignee:
INST FOR THEORETICAL MEDICINE INC (JP)
HINOKI SHINYAKU CO LTD (JP)
HINOKI SHINYAKU CO LTD (JP)
International Classes:
A61K31/472; A61K31/517; A61P3/10; A61P9/00; A61P9/10; A61P11/00; A61P19/02; A61P21/02; A61P25/00; A61P25/28; A61P29/00; A61P31/04; A61P35/00; A61P37/02
Other References:
YAMAZAKI YOSHIMITSU ET AL.: "Inhibitory effects of herbal alkaloids on the tumor necrosis factor-a and nitric oxide production in lipopolysaccharide-stimulated RAW264 macrophages", CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 59, no. 3, 2011, pages 388 - 391, XP055315854
BREZA NORA ET AL.: "Synthesis and characterization of novel quinazoline type inhibitors for mutant and wild-type EGFR and RICK kinases", JOURNAL OF RECEPTOR AND SIGNAL TRANSDUCTION RESEARCH, vol. 28, no. 4, 2008, pages 361 - 73
LI HONGLIANG ET AL.: "Papaverine improves sublingual blood flow in patients with septic shock", THE JOURNAL OF SURGICAL RESEARCH, vol. 195, no. 1, 13 January 2015 (2015-01-13), pages 271 - 276, XP055315859
GILMORE CHRISTOPHER D. ET AL.: "Orthogonal synthesis of indolines and isoquinolines via aryne annulation", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 130, no. 5, 2008, pages 1558 - 1559, XP055005341
YAGI YOSHIHIKO ET AL.: "Screening for inhibitors of the HMG-CoA reductase promoter in HepG2 cells: Identification of four non- oxysterol inhibitors", DRUG DEVELOPMENT RESEARCH, vol. 40, 1997, pages 41 - 47, XP055315876
FUTOSHI KITO ET AL.: "HMGB1/RAGE Bunshikan Sogo Sayo no Kaiseki", JOURNAL OF JAPANESE BIOCHEMICAL SOCIETY, 2009, pages 2P-434
BREZA NORA ET AL.: "Synthesis and characterization of novel quinazoline type inhibitors for mutant and wild-type EGFR and RICK kinases", JOURNAL OF RECEPTOR AND SIGNAL TRANSDUCTION RESEARCH, vol. 28, no. 4, 2008, pages 361 - 73
LI HONGLIANG ET AL.: "Papaverine improves sublingual blood flow in patients with septic shock", THE JOURNAL OF SURGICAL RESEARCH, vol. 195, no. 1, 13 January 2015 (2015-01-13), pages 271 - 276, XP055315859
GILMORE CHRISTOPHER D. ET AL.: "Orthogonal synthesis of indolines and isoquinolines via aryne annulation", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 130, no. 5, 2008, pages 1558 - 1559, XP055005341
YAGI YOSHIHIKO ET AL.: "Screening for inhibitors of the HMG-CoA reductase promoter in HepG2 cells: Identification of four non- oxysterol inhibitors", DRUG DEVELOPMENT RESEARCH, vol. 40, 1997, pages 41 - 47, XP055315876
FUTOSHI KITO ET AL.: "HMGB1/RAGE Bunshikan Sogo Sayo no Kaiseki", JOURNAL OF JAPANESE BIOCHEMICAL SOCIETY, 2009, pages 2P-434
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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