Title:
RAPAMYCIN NANOSCALE SUSTAINED-RELEASE AGENT AND PREPARATION METHOD THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/057007
Kind Code:
A1
Abstract:
Disclosed is a rapamycin nanoscale sustained-release agent prepared from the following raw materials in parts by weight: 1 part of rapamycin, 0.5-20 parts of soluble polymer carrier, 40-200 parts of organic solvent, and 400-20000 parts of aqueous phase. The rapamycin nanoscale sustained-release agent has a structure of nanomicelle and a particle size of 10-200 nm. The rapamycin nanoscale sustained-release agent presents low risk to blood vessels. The half-life of the rapamycin nanoscale sustained-release agent in the blood can be up to 50 hours or more. The rapamycin nanoscale sustained-release agent can directly reach the tumor-affected area. With continuous medication, the tumor regression rate can reach 50%.
Inventors:
YAN PENGKE (CN)
Application Number:
PCT/CN2020/082852
Publication Date:
April 01, 2021
Filing Date:
April 01, 2020
Export Citation:
Assignee:
YAN PENGKE (CN)
International Classes:
A61K9/107; A61K9/19; A61K31/436; A61K47/10; A61K47/32; A61K47/34; A61P35/00; A61P37/06
Domestic Patent References:
| WO2017139212A1 | 2017-08-17 |
Foreign References:
| CN110623925A | 2019-12-31 | |||
| CN102871966A | 2013-01-16 | |||
| CN105193732A | 2015-12-30 | |||
| CN102740834A | 2012-10-17 | |||
| CN109646403A | 2019-04-19 |
Attorney, Agent or Firm:
GUANGZHOU KEJIE INTELLECTUAL PROPERTY AGENCY (CN)
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