Title:
RAPESEED PEPTIDE AND USE THEREOF IN PREPARATION OF DRUG NANOCARRIERS
Document Type and Number:
WIPO Patent Application WO/2023/082243
Kind Code:
A1
Abstract:
Provided are a rapeseed peptide and a use thereof in the preparation of drug nanocarriers, relating to the technical field of biomedical materials. The rapeseed peptide has a sequence as shown in SEQ ID NO: 1, and can be applied to the preparation of drug nanocarriers. Also provided is a method for preparing an antitumor drug by using the peptide as a carrier, said method comprising the following steps: dissolving the rapeseed peptide and an antitumor drug in chloroform in sequence to obtain a mixed solution A; adding the mixed solution A dropwise to a phosphate buffer solution, and then adding Tween 80, stirring uniformly to obtain a mixed solution B; and removing chloroform from the mixed solution B to prepare an antitumor drug. The rapeseed peptide has a high embedding rate on drugs, significantly reduces the IC50 in drugs, and reduces the dosage of drugs.
Inventors:
HE RONG (CN)
WANG ZHIGAO (CN)
JU XINGRONG (CN)
YUAN JIAN (CN)
ZOU ZHIPENG (CN)
HUANG JIAQIANG (CN)
WANG MINGJIE (CN)
WANG ZHIGAO (CN)
JU XINGRONG (CN)
YUAN JIAN (CN)
ZOU ZHIPENG (CN)
HUANG JIAQIANG (CN)
WANG MINGJIE (CN)
Application Number:
PCT/CN2021/130617
Publication Date:
May 19, 2023
Filing Date:
November 15, 2021
Export Citation:
Assignee:
UNIV NANJING FINANCE & ECONOMICS (CN)
International Classes:
C07K7/06; A61K31/4745; A61K47/42; A61P35/00
Foreign References:
| CN101917866A | 2010-12-15 | |||
| CN107619844A | 2018-01-23 | |||
| CN104489237A | 2015-04-08 | |||
| CN110483812A | 2019-11-22 | |||
| US20080254505A1 | 2008-10-16 |
Other References:
WANG LIFENG, ZHANG JING, YUAN QIANG, XIE HUIHUI, SHI JIAYI, JU XINGRONG: "Separation and purification of an anti-tumor peptide from rapeseed (Brassica campestris L.) and the effect on cell apoptosis", FOOD & FUNCTION, R S C PUBLICATIONS, GB, vol. 7, no. 5, 1 January 2016 (2016-01-01), GB , pages 2239 - 2248, XP093066424, ISSN: 2042-6496, DOI: 10.1039/C6FO00042H
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