Title:
REACTION REAGENT FOR TRIFLUOROMETHYLATION
Document Type and Number:
WIPO Patent Application WO/2008/056677
Kind Code:
A1
Abstract:
Disclosed is a reaction reagent for trifluoromethylation, which has high versatility and good efficiency. Specifically disclosed is a reaction reagent for trifluoromethylation, which comprises an iron compound, iodinated trifluoromethyl, a sulfoxide and a peroxide. The reaction reagent may further comprise an acid. The iron compound may be iron (II) sulfate, ammonium iron (II) sulfate, iron (II) tetrafluoroborate, ferrocene, bis(η5-pentamethylcyclopentadienyl) iron or an iron powder. The sulfoxide may be dimethyl sulfoxide. The peroxide may be hydrogen peroxide or a hydrogen peroxide-urea complex. The acid may be sulfuric acid, tetrafluoroboric acid or trifluoromethanesulfonic acid.
Inventors:
YAMAKAWA TETSU (JP)
YAMAMOTO KYOKO (JP)
URAGUCHI DAISUKE (JP)
TOKUHISA KENJI (JP)
YAMAMOTO KYOKO (JP)
URAGUCHI DAISUKE (JP)
TOKUHISA KENJI (JP)
Application Number:
PCT/JP2007/071575
Publication Date:
May 15, 2008
Filing Date:
November 06, 2007
Export Citation:
Assignee:
SAGAMI CHEM RES (JP)
TOSOH F TECH INC (JP)
YAMAKAWA TETSU (JP)
YAMAMOTO KYOKO (JP)
URAGUCHI DAISUKE (JP)
TOKUHISA KENJI (JP)
TOSOH F TECH INC (JP)
YAMAKAWA TETSU (JP)
YAMAMOTO KYOKO (JP)
URAGUCHI DAISUKE (JP)
TOKUHISA KENJI (JP)
International Classes:
C07B39/00; C07C17/32; C07C22/08; C07C209/68; C07C211/52; C07D213/64; C07D231/12; C07D239/54; C07D473/16; C07D473/18
Domestic Patent References:
| WO2007055170A1 | 2007-05-18 |
Foreign References:
| US3271441A | 1966-09-06 | |||
| JP2006300571A | 2006-11-02 |
Other References:
J. MED. CHEM., vol. 40, no. 11, 1997, pages 1619 - 1633, XP002059990
BIOORG. MED. CHEM. LETT., vol. 16, no. 14, 2006, pages 3657 - 3662, XP005477307
TETRAHEDRON LETTERS, vol. 31, 1990, pages 3579 - 3582
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 115, 1993, pages 2156 - 2164
JOURNAL OF ORGANIC CHEMISTRY, vol. 59, 1994, pages 5692 - 5699
JOURNAL OF FLUORINE CHEMISTRY, vol. 74, 1995, pages 77 - 82
JOURNAL OF ORGANIC CHEMISTRY, vol. 68, 2003, pages 8726 - 8729
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 107, 1985, pages 5014 - 5015
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 108, 1986, pages 832 - 834
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY, vol. 41, 1983, pages 251 - 265
JOURNAL OF ORGANIC CHEMISTRY, vol. 53, 1988, pages 4582 - 4585
JOURNAL OF CHEMICAL SOCIETY, 1980, pages 2755 - 2761
ORGANIC LETTERS, vol. 7, 2005, pages 4883 - 4885
JOURNAL OF CHEMICAL SOCIETY, PERKIN TRANSACTION I, 1990, pages 2293 - 2299
JOURNAL OF FLUORINE CHEMISTRY, vol. 75, 1995, pages 115 - 116
JOURNAL OF ORGANIC CHEMISTRY, vol. 62, 1997, pages 7128 - 7136
TETRAHEDRON LETTERS, vol. 34, 1993, pages 3799 - 3800
See also references of EP 2080744A4
BIOORG. MED. CHEM. LETT., vol. 16, no. 14, 2006, pages 3657 - 3662, XP005477307
TETRAHEDRON LETTERS, vol. 31, 1990, pages 3579 - 3582
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 115, 1993, pages 2156 - 2164
JOURNAL OF ORGANIC CHEMISTRY, vol. 59, 1994, pages 5692 - 5699
JOURNAL OF FLUORINE CHEMISTRY, vol. 74, 1995, pages 77 - 82
JOURNAL OF ORGANIC CHEMISTRY, vol. 68, 2003, pages 8726 - 8729
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 107, 1985, pages 5014 - 5015
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 108, 1986, pages 832 - 834
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY, vol. 41, 1983, pages 251 - 265
JOURNAL OF ORGANIC CHEMISTRY, vol. 53, 1988, pages 4582 - 4585
JOURNAL OF CHEMICAL SOCIETY, 1980, pages 2755 - 2761
ORGANIC LETTERS, vol. 7, 2005, pages 4883 - 4885
JOURNAL OF CHEMICAL SOCIETY, PERKIN TRANSACTION I, 1990, pages 2293 - 2299
JOURNAL OF FLUORINE CHEMISTRY, vol. 75, 1995, pages 115 - 116
JOURNAL OF ORGANIC CHEMISTRY, vol. 62, 1997, pages 7128 - 7136
TETRAHEDRON LETTERS, vol. 34, 1993, pages 3799 - 3800
See also references of EP 2080744A4
Attorney, Agent or Firm:
SENMYO, Kenji et al. (SIA Kanda Square17, Kanda-konyach, Chiyoda-ku Tokyo 35, JP)
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