Title:
REACTIVE OXYGEN SPECIES (ROS) PRODUCTION PROMOTER
Document Type and Number:
WIPO Patent Application WO/2023/027164
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing an ROS production promoter. The present invention provides an ROS production promoter that contains an agent that recognizes a transferrin receptor.
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Inventors:
KATSUMI KEIKO (JP)
OYA JUNPEI (JP)
ISHII KEISUKE (JP)
SAKAMOTO AYA (JP)
OYA JUNPEI (JP)
ISHII KEISUKE (JP)
SAKAMOTO AYA (JP)
Application Number:
PCT/JP2022/032161
Publication Date:
March 02, 2023
Filing Date:
August 26, 2022
Export Citation:
Assignee:
PERSEUS PROTEOMICS INC (JP)
International Classes:
A61K45/00; A61K39/395; A61P35/00; A61P39/06; A61P43/00
Domestic Patent References:
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| WO2020104479A1 | 2020-05-28 | |||
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| WO2014073641A1 | 2014-05-15 | |||
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JEONG SEUNG MIN; HWANG SUNSOOK; SEONG RHO HYUN: "Transferrin receptor regulates pancreatic cancer growth by modulating mitochondrial respiration and ROS generation", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM NL, vol. 471, no. 3, 8 February 2016 (2016-02-08), Amsterdam NL , pages 373 - 379, XP029440037, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2016.02.023
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HASHIMOTO-GOTOH, TMIZUNO, TOGASAHARA, YDNA KAGAWA, M.: "An oligodeoxyribonucleotide-directed dual amber method for site-directed mutagenesis", GENE, vol. 152, 1995, pages 271 - 275, XP004042690, DOI: 10.1016/0378-1119(94)00750-M
ZOLLER, MJSMITH, M.: "Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors", METHODS ENZYMOL., vol. 100, 1983, pages 468 - 500, XP001088749, DOI: 10.1016/0076-6879(83)00074-9
KRAMER, WDRUTSA, VJANSEN, HWKRAMER, BPFLUGFELDER, MFRITZ, HJ: "The gapped duplex DNA approach to oligonucleotide-directed mutation construction", NUCLEIC ACIDS RES., vol. 12, 1984, pages 9441 - 9456, XP002026371
KRAMER WFRITZ HJ: "Oligonucleotide-directed construction of mutations via gapped duplex DNA Methods", ENZYMOL., vol. 154, 1987, pages 350 - 367
KUNKEL, TA: "Rapid and efficient site-specific mutagenesis without phenotypic selection", PROC NATL ACAD SCI USA., vol. 82, 1985, pages 488 - 492, XP002052322, DOI: 10.1073/pnas.82.2.488
KABAT, E. A. ET AL.: "Sequences of Proteins of Immunological Interest", 1991, U. S. DEPARTMENT OF HEALTH AND HUMAN SERVICES
A. WRIGHTS. L. MORRISON, J. IMMUNOL., vol. 160, 1998, pages 3393 - 3402
K. MOTMANS ET AL., EUR. J. CANCER PREV., vol. 5, 1996, pages 512 - 5199
R. P. JUNGHANS ET AL., CANCER RES., vol. 50, 1990, pages 1495 - 1502
R. W. MALONE ET AL., PROC. NATL. ACAD. SCI. USA, vol. 86, 1989, pages 6007
P. L. FELGNER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 84, 1987, pages 7413
F. L. GRAHAMA. J. VAN DER EB, VIROLOGY, vol. 52, 1973, pages 456 - 467
SHIM, H.: "Bispecific Antibodies and Antibody-Drug Conjugates for Cancer Therapy: Technological Considerations", BIOMOLECULES, vol. 10, 2020, pages 360
MATTIA ELENA, JOSIC DJURO, ASHWELL GILBERT, KLAUSNER RICHARD, VAN RENSWOUDE JOS: "Regulation of Intracellular Iron Distribution in K562 Human Erythroleukemia Cells", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 261, no. 10, 5 April 1986 (1986-04-05), pages 4587 - 4593, XP093038713, DOI: 10.1016/S0021-9258(17)38542-3
DU JING; WANG TONGTONG; LI YANCHUN; ZHOU YI; WANG XIN; YU XINGXING; REN XUEYING; AN YIHAN; WU YI; SUN WEIDONG; FAN WEIMIN; ZHU QIA: "DHA inhibits proliferation and induces ferroptosis of leukemia cells through autophagy dependent degradation of ferritin", FREE RADICAL BIOLOGY & MEDICINE, ELSEVIER INC, US, vol. 131, 1 January 1900 (1900-01-01), US , pages 356 - 369, XP085577081, ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2018.12.011
JEONG SEUNG MIN; HWANG SUNSOOK; SEONG RHO HYUN: "Transferrin receptor regulates pancreatic cancer growth by modulating mitochondrial respiration and ROS generation", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM NL, vol. 471, no. 3, 8 February 2016 (2016-02-08), Amsterdam NL , pages 373 - 379, XP029440037, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2016.02.023
WILNER ET AL., MOLECULAR THERAPY-NUCLEIC ACIDS, vol. 1, 2012, pages e21
JAE H. LEE ET AL., EUR. J. BIOCHEM., vol. 268, 2001, pages 2004 - 2012
WINTER ET AL., IMMUNOL. TODAY, vol. 14, 1993, pages 43 - 46
HASHIMOTO-GOTOH, TMIZUNO, TOGASAHARA, YDNA KAGAWA, M.: "An oligodeoxyribonucleotide-directed dual amber method for site-directed mutagenesis", GENE, vol. 152, 1995, pages 271 - 275, XP004042690, DOI: 10.1016/0378-1119(94)00750-M
ZOLLER, MJSMITH, M.: "Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors", METHODS ENZYMOL., vol. 100, 1983, pages 468 - 500, XP001088749, DOI: 10.1016/0076-6879(83)00074-9
KRAMER, WDRUTSA, VJANSEN, HWKRAMER, BPFLUGFELDER, MFRITZ, HJ: "The gapped duplex DNA approach to oligonucleotide-directed mutation construction", NUCLEIC ACIDS RES., vol. 12, 1984, pages 9441 - 9456, XP002026371
KRAMER WFRITZ HJ: "Oligonucleotide-directed construction of mutations via gapped duplex DNA Methods", ENZYMOL., vol. 154, 1987, pages 350 - 367
KUNKEL, TA: "Rapid and efficient site-specific mutagenesis without phenotypic selection", PROC NATL ACAD SCI USA., vol. 82, 1985, pages 488 - 492, XP002052322, DOI: 10.1073/pnas.82.2.488
KABAT, E. A. ET AL.: "Sequences of Proteins of Immunological Interest", 1991, U. S. DEPARTMENT OF HEALTH AND HUMAN SERVICES
A. WRIGHTS. L. MORRISON, J. IMMUNOL., vol. 160, 1998, pages 3393 - 3402
K. MOTMANS ET AL., EUR. J. CANCER PREV., vol. 5, 1996, pages 512 - 5199
R. P. JUNGHANS ET AL., CANCER RES., vol. 50, 1990, pages 1495 - 1502
R. W. MALONE ET AL., PROC. NATL. ACAD. SCI. USA, vol. 86, 1989, pages 6007
P. L. FELGNER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 84, 1987, pages 7413
F. L. GRAHAMA. J. VAN DER EB, VIROLOGY, vol. 52, 1973, pages 456 - 467
SHIM, H.: "Bispecific Antibodies and Antibody-Drug Conjugates for Cancer Therapy: Technological Considerations", BIOMOLECULES, vol. 10, 2020, pages 360
Attorney, Agent or Firm:
SIKS & CO. (JP)
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