Title:
REAGENT FOR MEASURING OXYGEN CONCENTRATION IN CELL AND TISSUE
Document Type and Number:
WIPO Patent Application WO/2021/039789
Kind Code:
A1
Abstract:
The present invention addresses the problem of developing a reagent and a compound having a long phosphorescence lifetime for imaging of a low-oxygen cell or tissue, or measurement or quantification of the oxygen concentration in the low-oxygen cell or tissue. The present invention provides an oxygen concentration measurement reagent which contains a compound represented by general formula (I) or (II). (In the formulae, each of R1 and R2 independently represents a hydrogen atom or a hydrocarbon group having from 1 to 6 carbon atoms; and X- represents a counter anion.)
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Inventors:
YOSHIHARA TOSHITADA (JP)
HIROSE TATSUYA (JP)
TOBITA SEIJI (JP)
HIROSE TATSUYA (JP)
TOBITA SEIJI (JP)
Application Number:
PCT/JP2020/032028
Publication Date:
March 04, 2021
Filing Date:
August 25, 2020
Export Citation:
Assignee:
UNIV GUNMA NAT UNIV CORP (JP)
International Classes:
C07D417/04; A61K49/10; C07D491/16; C07F15/00; C09K11/06; G01N21/78; G01N31/00; G01N33/483
Foreign References:
| JP2015101567A | 2015-06-04 | |||
| CN106478731A | 2017-03-08 | |||
| JPS4930943B1 | 1974-08-17 | |||
| JP5353509B2 | 2013-11-27 | |||
| JP2015101567A | 2015-06-04 |
Other References:
TAKIZAWA, SHIN-YA, IKUTA NAOYA, ZENG FANYANG, KOMARU SHOHEI, SEBATA SHINOGU, MURATA SHIGERU: "Impact of Substituents on Excited-State and Photosensitizing Properties in Cationic Iridium(III) Complexes with Ligands of Coumarin 6", INORGANIC CHEMISTRY, vol. 55, no. 17, 2016, pages 8723 - 8735, XP055797523, DOI: 10.1021/acs.inorgchem.6b01279
YOSHIHARA, TOSHITADA, HOSAKA MASAHIRO, TERATA MOTOKI, ICHIKAWA KAZUKI, MURAYAMA SAORI, TANAKA ASAMI, MORI MASANOBU, ITABASHI HIDEY: "Intracellular and in Vivo Oxygen Sensing Using Phosphorescent Ir(III) Complexes with a Modified Acetylacetonato Ligand", ANALYTICAL CHEMISTRY, vol. 87, no. 5, March 2015 (2015-03-01), pages 2710 - 2717, XP055797527, DOI: 10.1021/ac5040067
TATSUYA HIROSE, TOSHITADA YOSHIHARA, TERUICHI MIZUKAMI, AYAKA KATANO, SHUICHI SHIOZAKI, SHIGEFUMI TOBITA: "3P103 Development of Ir (III) complexes based on coumarin derivative as a ligand and their application to an In vivo oxygen imaging", ABSTRACTS OF ANNUAL MEETING OF PHOTOCHEMISTRY; SEPTEMBER 10 TO 12, 2019, 10 September 2019 (2019-09-10) - 12 September 2019 (2019-09-12), JP, pages 1 - 2, XP009538847
T. V. ESIPOVA ET AL., ANAL. CHEM., vol. 83, 2011, pages 8756 - 8765
S. ZHANG ET AL., CANCER RES., vol. 70, 2010, pages 4490 - 4498
T. YOSHIHARA ET AL., ANAL. CHEM., vol. 87, 2015, pages 2710 - 2717
A. FERCHER ET AL., ACS NANO, vol. 5, 2011, pages 5499 - 5508
INORG. CHEM., vol. 55, no. 17, 2016, pages 8723 - 8735
YOSHIHARA, TOSHITADA, HOSAKA MASAHIRO, TERATA MOTOKI, ICHIKAWA KAZUKI, MURAYAMA SAORI, TANAKA ASAMI, MORI MASANOBU, ITABASHI HIDEY: "Intracellular and in Vivo Oxygen Sensing Using Phosphorescent Ir(III) Complexes with a Modified Acetylacetonato Ligand", ANALYTICAL CHEMISTRY, vol. 87, no. 5, March 2015 (2015-03-01), pages 2710 - 2717, XP055797527, DOI: 10.1021/ac5040067
TATSUYA HIROSE, TOSHITADA YOSHIHARA, TERUICHI MIZUKAMI, AYAKA KATANO, SHUICHI SHIOZAKI, SHIGEFUMI TOBITA: "3P103 Development of Ir (III) complexes based on coumarin derivative as a ligand and their application to an In vivo oxygen imaging", ABSTRACTS OF ANNUAL MEETING OF PHOTOCHEMISTRY; SEPTEMBER 10 TO 12, 2019, 10 September 2019 (2019-09-10) - 12 September 2019 (2019-09-12), JP, pages 1 - 2, XP009538847
T. V. ESIPOVA ET AL., ANAL. CHEM., vol. 83, 2011, pages 8756 - 8765
S. ZHANG ET AL., CANCER RES., vol. 70, 2010, pages 4490 - 4498
T. YOSHIHARA ET AL., ANAL. CHEM., vol. 87, 2015, pages 2710 - 2717
A. FERCHER ET AL., ACS NANO, vol. 5, 2011, pages 5499 - 5508
INORG. CHEM., vol. 55, no. 17, 2016, pages 8723 - 8735
Attorney, Agent or Firm:
IP FIRM SHUWA (JP)
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