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Title:
RECOMBINANT BOVINE THROMBIN
Document Type and Number:
WIPO Patent Application WO2003052059
Kind Code:
A3
Abstract:
Methods are disclosed for producing recombinant thrombin from precursor molecules that do not require activation by Factor Xa. The protein is produced from host cells transformed or transfected with DNA construct(s) containing information necessary to direct the expression of thrombin precursors. Methods for purification of the thrombin precursors are also described. Thrombin precursors produced from transformed or transfected host cells are auto-activated or secreted in an activated form.

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Inventors:
FRYE CHRISTOPHER CARL (US)
HERSHBERGER CHARLES LEE (US)
Application Number:
PCT/US2002/036146
Publication Date:
October 30, 2003
Filing Date:
December 05, 2002
Export Citation:
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Assignee:
LILLY CO ELI (US)
FRYE CHRISTOPHER CARL (US)
HERSHBERGER CHARLES LEE (US)
International Classes:
C12N1/21; C12N9/64; C12N15/00; (IPC1-7): C07H21/02; C07H21/04; C07K1/00; C07K14/00; C12N1/21; C12N9/00; C12N9/74; C12N15/00; C12N15/63; C12N15/85; C12N15/86
Other References:
DATABASE GENBANK [online] 1 April 1990 (1990-04-01), XP002965089, accession no. MEDLINE Database accession no. (P00735)
PEI ET AL.: "Expression, isolation and characterization of an active site (Serine 528 to alanine) mutant of recombinant bovine prothrombin", J. BIOL. CHEM., vol. 266, no. 15, 25 May 1991 (1991-05-25), pages 9598 - 9604, XP002931780
DIBELLA ET AL.: "Expression and folding of recombinant bovine prethrombin-2 and its activation to thrombin", J. BIOL. CHEM., vol. 270, no. 1, 6 January 1995 (1995-01-06), pages 163 - 169, XP002149152
See also references of EP 1458736A4
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