Title:
RECOMBINANT CHIMERIC PROTEIN OF NEUTROPHIL INHIBITORY FACTOR AND HIRUGEN AND MEDICAMENT COMPOSITION THEREOF
Document Type and Number:
WIPO Patent Application WO/2008/101415
Kind Code:
A1
Abstract:
Provided is a chimeric protein comprising neutrophil inhibitory factor, the
peptide FPRP specially recognizing the thrombin active site and hirugen. Also
provided is the medicament composition comprising the chimeric protein, which
can be used for treating or preventing cerebral injury and cerebral edema, inhibiting
platelet aggregation etc.
Inventors:
FAN KAI (CN)
ZHAO ZHIQUAN (CN)
ZHAO ZHIQUAN (CN)
Application Number:
PCT/CN2008/000359
Publication Date:
August 28, 2008
Filing Date:
February 18, 2008
Export Citation:
Assignee:
LUNAN PHARM GROUP CORP (CN)
FAGEN BIOMEDICAL INC CHONGQING (CN)
FAN KAI (CN)
ZHAO ZHIQUAN (CN)
FAGEN BIOMEDICAL INC CHONGQING (CN)
FAN KAI (CN)
ZHAO ZHIQUAN (CN)
International Classes:
C07K19/00; A61K38/58; A61P7/02; C12N15/62; C12N15/63; C12N15/70; C07K14/435; C07K14/815
Foreign References:
| CN1517365A | 2004-08-04 | |||
| CN31011551A | ||||
| CN31011551A |
Other References:
YANG H. ET AL.: "Comparison of protective effects of gene engineering agents, NIF, NHH or TNHH on focal cerebral ischemia injury in rats subjected to middle cerebral artery occlusion", CHINA PHARMACY, vol. 15, no. 6, 2004, pages 337 - 338, XP008131582
WANG Y. ET AL.: "Hirudin and Hirulog-two kinds of new Antithrombotic agent", SCI/TECH INFORMATION DEVELOPMENT & ECONOMY, vol. 10, no. 5, 2000, pages 60 - 61, XP008131579
LIU G. ET AL.: "The anticoagulative activity of synthetic C-terminus of desulfo hirudin and its analogus", CHINESE JOURNAL OF MEDICINAL CHEMISTRY, vol. 8, no. 1, March 1998 (1998-03-01), pages 14 - 18, 23, XP008116831
MADDEN KETAL, INFLAMM RES, vol. 46, no. 6, 1997, pages 216 - 223
MASADDA T. ET AL., BRAIN RES, vol. 867, no. 2, 2000, pages 173 - 179
MOYLE M ET AL., J BIOL CHEM, vol. 269, no. 13, 1994, pages 10008 - 10015
ZHANG L, STROKE, vol. 34, no. 7, 2003, pages 1790 - 1795
NASKI ET AL., J BIOCCHEM., vol. 265, no. 23, 1990, pages 13484 - 13489
MARAGANORE, J METAL: BIOCHEMISTRY., vol. 29, no. 30, 1990, pages 7095 - 7101
KARLIN; ALTSCHUL, PROC. NATL. ACAD. SCI. USA, vol. 87, 1990, pages 2264 - 2268
PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873
See also references of EP 2123680A4
WANG Y. ET AL.: "Hirudin and Hirulog-two kinds of new Antithrombotic agent", SCI/TECH INFORMATION DEVELOPMENT & ECONOMY, vol. 10, no. 5, 2000, pages 60 - 61, XP008131579
LIU G. ET AL.: "The anticoagulative activity of synthetic C-terminus of desulfo hirudin and its analogus", CHINESE JOURNAL OF MEDICINAL CHEMISTRY, vol. 8, no. 1, March 1998 (1998-03-01), pages 14 - 18, 23, XP008116831
MADDEN KETAL, INFLAMM RES, vol. 46, no. 6, 1997, pages 216 - 223
MASADDA T. ET AL., BRAIN RES, vol. 867, no. 2, 2000, pages 173 - 179
MOYLE M ET AL., J BIOL CHEM, vol. 269, no. 13, 1994, pages 10008 - 10015
ZHANG L, STROKE, vol. 34, no. 7, 2003, pages 1790 - 1795
NASKI ET AL., J BIOCCHEM., vol. 265, no. 23, 1990, pages 13484 - 13489
MARAGANORE, J METAL: BIOCHEMISTRY., vol. 29, no. 30, 1990, pages 7095 - 7101
KARLIN; ALTSCHUL, PROC. NATL. ACAD. SCI. USA, vol. 87, 1990, pages 2264 - 2268
PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873
See also references of EP 2123680A4
Attorney, Agent or Firm:
LUNG TIN INTERNATIONAL INTELLECTUAL PROPERTY AGENT LTD. (Tower B Grand Place,No. 5, Huizhong Road,Chaoyang District, Beijing 1, CN)
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